MOLECULAR BASIS OF CANCER/SIGNALING TO CELL GROWTH/DEATH

在我们对细胞生长和死亡是如何调节的理解以及控制这些细胞反应的信号通路方面已经取得了相当大的进展。最近，在理解这些途径如何交叉以及一种反应的失调如何影响其他反应方面取得了令人兴奋的新进展。现在清楚的是，驱动细胞增殖的致癌改变也激活生长抑制途径，并且信号细胞生长、死亡和存活的途径可以密切联系并响应于相同的信号而被激活。肿瘤细胞进展是互补反应途径中的扰动的反映，其允许恶性细胞存活和生长。本次会议将汇集细胞生长和凋亡与调节它们的信号转导机制的领域，以帮助巩固我们对这些反应如何在正常细胞中调节以及肿瘤进展所需的失调模式的理解。发言者的选择主要是基于对会议总体科学目标的贡献。这三个共同组织者代表了信号转导和调节癌症细胞生长和死亡领域的广泛专业知识，我们希望在会议上将这些主题聚集在一起。将这些领域聚集在一次会议上是一个新的步骤，将引起许多癌症生物学家的广泛兴趣，特别适合新一代进入该领域的年轻科学家。幸运的是，这些领域都有妇女专家，她们既是特邀发言人，也是组织者。该会议也将特别关注制药行业，来自公司的演讲者也包括在该计划中。

Considerable advances have been made in our understanding of how cell growth and death are regulated, and the signaling pathways that control these cellular responses. Recently, exciting new advances have been made in understanding how these pathways intersect, and how deregulation of one response impinges on others. It is now clear that oncogenic alterations that drive cell proliferation also activate growth inhibitory pathways, and pathways that signal cell growth, death and survival can be intimately linked and activated in response to the same signal. Tumor cell progression is a reflection of perturbations in complementary response pathways that allow malignant cells to survive and grow. This meeting will bring together areas of cell growth and apoptosis with signal transduction mechanisms that regulate them, to help consolidate our understanding of how these responses are regulated in normal cells and patterns of deregulation that are required for tumor progression. The choice of speakers has been based primarily on the contribution to the overall scientific goal of the conference. The three co-organizers represent a wide range of expertise in the areas of signal transduction and regulation of cell growth and death in cancers, the subjects we are hoping to bring together in the meeting. Bringing together these fields in one meeting is a new step that will be of wide interest to many cancer biologists, and will be particularly appropriate for the new generation of younger scientists entering the field. Fortunately these areas are well represented by experts who are women, who are well represented as both invited speakers and organizers. This meeting will also be of particular interest to the pharmaceutical industry and speakers from companies are also included in the program.