CONFERENCE ON MOLECULAR CLOCKS

描述(申请人摘要)：对一个特别的结果印象深刻 超额认购分子钟国际会议在北京召开 胡安·马奇基金会1998年5月，关于这一主题的一次重要会议是 建议于2001年举行。要表示的子区域包括(1)分子和 动物系统昼夜行为节律的遗传学研究 强调新发现的基因，时钟基因之间的强烈同源性 动物王国，以及它们的作用机制。(2)分子途径 这提供了重置时钟和睡眠/唤醒周期对光的反应。 我们对光转导相关分子机制的理解 仅在过去的一年里，时钟基因的反应就大幅增长。这个 在某些系统中，作为昼夜节律光感受器的隐色素的作用， 现在得到了广泛的研究。(3)觉醒/睡眠行为的调节。生化 将信号从分子时钟传递到定时行为的策略有 在过去的一年里得到了澄清。(4)人类觉醒/睡眠的基因控制 循环。人类昼夜节律的第一个遗传变异是 以及对发作性睡病的部分分子描述 哺乳动物模型。(5)植物、真菌和细菌钟，以及建模 分子振荡器。非动物模型系统继续提供我们的一些 对昼夜节律[时钟]背后的生化机制的最大见解。

DESCRIPTION (Applicant's Abstract): Impressed by the results of a particularly successful and oversubscribed international meeting on Molecular Clocks held at the Juan March Foundation in May of 1998, a Keystone meeting on the subject is proposed for 2001. The sub-areas to be represented include (1) Molecular and genetics studies of circadian behavioral rhythms in animal systems, with emphasis on newly identified genes, the strong homologies among clock genes in the animal kingdom, and their mechanisms of action. (2) The molecular pathways that afford resetting of clocks and the sleep/wake cycle in response to light. Our understanding of the molecular mechanisms associated with phototransduction and clock gene responses has grown significantly in just the past year. The role of cryptochromes, which act as circadian photoreceptors in some systems, is now widely studied. (3) Regulation of wake/sleep behavior. Biochemical strategies for conveying signals from molecular clocks to timed behavior have been clarified in the past year. (4) Genetic control of human wake/sleep cycles. The first hereditary variations in human circadian rhythms were reported last year as well as a partial molecular description of narcolepsy in mammalian models. (5) Plant, fungal, and bacterial clocks, and modeling molecular oscillators. Non-animal model systems continue to provide some of our greatest insights into biochemical mechanisms underlying circadian [clocks].