INTEGRATED UPGRADE OF THE NMR INSTRUMENTATION FACILITY

核磁共振仪器设施综合升级

• 批准号: 6052307
• 负责人: George L McLendon
• 金额: $ 25.47万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6052307
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

The Department of Chemistry at Princeton University requests funds from the National Center for Research Resources (NCRR) for the purpose of an integrated upgrade of the NMR instrumentation facility, with the focus on biomolecular and bioanalytical applications. The centerpiece for this integrated upgrade is a new 400 MHz NMR spectrometer, which will replace an outdated machine and remove the bottleneck of routine and semi-routine applications. At the same time this enhancement will allow more efficient use of the existing high-field spectrometers for demanding biomolecular research. Additional items of the integrated upgrade will extend the capacity of these high-field instruments. They will open new research opportunities and serve critical research needs primarily in the field of structure, characterization, and dynamics studies of biomolecules. These units are: a complete LC-NMR accessory kit, a slow-spinning high- resolution MAS probehead, a 13C-15N detection optimized triple resonance probehead and a modern computer for efficient off-line data analysis and structure calculations. This upgrade is critical to the success of the research projects in the Department, specifically those of the core user group of eleven faculty members. When implemented, this integrated upgrade of the NMR instrumentation facility will have greatly expanded our total capabilities and increased the efficiency of the highest field NMR spectrometers and associated units, critical for biostructural studies , for a modest total investment.

普林斯顿大学化学系要求国家研究资源中心（NCRR）提供资金，用于NMR仪器设备的综合升级，重点是生物分子和生物分析应用。此次集成升级的核心是一台新的400 MHz NMR光谱仪，它将取代过时的机器，并消除常规和半常规应用的瓶颈。与此同时，这种增强将允许更有效地使用现有的高场光谱仪，用于要求苛刻的生物分子研究。综合升级的其他项目将扩大这些高场仪器的能力。它们将开辟新的研究机会，并主要在生物分子的结构，表征和动力学研究领域提供关键的研究需求。这些单位是：一个完整的LC-NMR附件套件，一个慢旋转高分辨率MAS探头，一个13 C-15 N检测优化的三重共振探头和一个现代化的计算机，用于高效的离线数据分析和结构计算。这一升级是至关重要的研究项目在部门的成功，特别是那些核心用户群的11名教员。实施后，核磁共振仪器设施的集成升级将大大扩展我们的总能力，并提高最高现场核磁共振光谱仪和相关单元的效率，这对生物结构研究至关重要，而且总投资不多。