Exploring the origins and activation dynamics of the endometriosis-associated macrophage in a novel mouse model

在新型小鼠模型中探索子宫内膜异位症相关巨噬细胞的起源和激活动力学

• 批准号: 1789503
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1789503
• 关键词: Exploring; origins; activation; dynamics; endometriosis

Endometriosis is a chronic inflammatory condition that affects 1 in 10 women of reproductive age. It is associated with debilitating pelvic pain and infertility and has a huge adverse impact on health-related quality of life. Current therapies are limited to surgery or hormonal suppression. Women want new alternatives to current treatment options.

子宫内膜异位症是一种慢性炎症性疾病，每10名育龄妇女中就有1名受到影响。它与骨盆疼痛和不孕症有关，并对健康相关的生活质量产生巨大的不利影响。目前的治疗方法仅限于手术或激素抑制。女性希望有新的替代方案来替代目前的治疗方案。

项目成果

Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications.

• DOI: 10.3390/biomedicines10010185
• 发表时间: 2022-01-17
• 期刊: Biomedicines
• 影响因子: 4.7
• 作者: Chang CY;Chiang AJ;Yan MJ;Lai MT;Su YY;Huang HY;Chang CY;Li YH;Li PF;Chen CM;Hwang T;Hogg C;Greaves E;Sheu JJ
• 通讯作者: Sheu JJ

Macrophages inhibit and enhance endometriosis depending on their origin.

• DOI: 10.1073/pnas.2013776118
• 发表时间: 2021-02-09
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Hogg C;Panir K;Dhami P;Rosser M;Mack M;Soong D;Pollard JW;Jenkins SJ;Horne AW;Greaves E
• 通讯作者: Greaves E