Cerebellar substrates of age-related learning deficits

与年龄相关的学习缺陷的小脑基质

• 批准号: 6446764
• 负责人: MATTHEW A SEAGER
• 金额: $ 3.43万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-10-15 至 2002-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446764
• 关键词: age difference; animal old age; behavior test; behavioral /social science research tag; biological models; cell population study; cerebellar Purkinje cell; cerebellum; conditioning; developmental neurobiology; electrophysiology; geriatrics; juvenile animal; laboratory rabbit; learning disorders; neural information processing; neural plasticity; neural transmission; neuropsychology; nictitating membrane; postdoctoral investigator; psychological aspect of aging; reflex; synapses

DESCRIPTION (provided by applicant): With aged individuals comprising an increasing proportion of the world?s population, care and treatment of age-related disorders is of utmost importance. In the United States alone, the percentage of the population over 65 rose to 12 percent in the 1990s and will grow to 16 percent with the aging of the "baby-boomer" generation. The process of aging has many deleterious effects on both physical and mental functioning, including a decline or slowing in cognitive function. This cognitive decline is a usual consequence of both nominal and abnormal (e.g, Alzheimer?s disease) aging and typically manifests itself in the domain of learning and memory. The use of animal models has become an invaluable tool in our search to understand the biological substrates of learning and the deleterious effects of aging. Classical conditioning of the rabbit?s nictitating membrane (NM)/eyeblink response is an ideal paradigm in which to study aging. Age-related deficits have been reported for this task, but the underlying changes in the neural substrates have thus far been under investigated. The current proposal will examine age-related functional changes in cerebellar circuitry that is critically involved in this task. With the use of elecirophysiological techniques in in vitro slices, we hope to document differences in cellular excitability and synaptic plasticity between young and aging brain. These differences could help explain the age-related disruption of learning and ultimately lead to the development of therapeutic strategies.

描述(由申请人提供)：年长人士包括 世界人口比例越来越大？S的人口、护理和治疗 与年龄相关的疾病是最重要的。仅在美国， 65岁以上人口的比例在20世纪90年代上升到12%，并将 随着婴儿潮一代的老龄化，这一比例将增长到16%。 衰老的过程对身体和精神都有许多有害的影响 功能障碍，包括认知功能的下降或减慢。这 认知能力下降通常是名义和异常的结果(例如， 阿尔茨海默病？S病)衰老，典型地表现在 学习和记忆。动物模型的使用已经成为一种宝贵的工具 我们寻求了解学习的生物学基础和 衰老的有害影响。兔的经典条件作用--S 瞬膜(NM)/眨眼反应是一种理想的 研究衰老。据报道，这项任务与年龄相关的缺陷，但 到目前为止，神经基质的潜在变化一直处于 调查过了。目前的提案将审查与年龄相关的功能变化 在这项任务中起关键作用的是小脑回路。随着使用 在体外切片的电生理技术方面，我们希望记录 青年和青少年细胞兴奋性和突触可塑性的差异 大脑老化。这些差异可能有助于解释与年龄相关的脑电活动中断 学习并最终导致治疗策略的发展。

项目成果

Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: US intensity effects.

兔子（Oryctolagus cuniculus）瞬膜反应的条件特异性反射修饰：美国强度效应。

• DOI: 10.3758/bf03195990
• 发表时间: 2003
• 期刊: Learning & behavior
• 影响因子: 1.8
• 作者: Seager,MatthewA;Smith-Bell,CarrieA;Schreurs,BernardG
• 通讯作者: Schreurs,BernardG