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ELASTICITY OF KINESIN UNDER ROTARY AND LINEAR FORCES

ELASTICITY OF KINESIN UNDER ROTARY AND LINEAR FORCES
旋转力和线性力下驱动蛋白的弹性
批准号：
6374822
负责人：
WILLIAM R. SCHIEF
金额：
$4.02万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
未结题
起止时间：
2001-09-30 至
来源：
https://reporter.nih.gov/project-details/6374822
关键词：
animal tissue biomechanics elasticity kinesin mechanical stress microtubules nanotechnology video microscopy

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英文摘要
Understanding how any motor works requires specifying the motor's mechanical components and determining how these components move and interact during the force-generating process. The internal workings of motor proteins, which power muscle contraction, propel swimming sperm, and carry organelles along tracks in cells, are not understood. This proposal intends to reveal the mechanical elastic components of the motor protein kinesin. The specific aims are: to measure the elasticity of kinesin under (1) torsional, (2) longitudinal, and (3) extensional forces, to locate the corresponding molecular compliant elements, and to evaluate the impact of these external forces on kinesin force generation. Optical tweezers and calibrated force fibers will be used to measure force and displacement of single-molecules for the characterization of motor elastic properties. Recombinant protein expression techniques will be utilized to identify the elastic components. The information obtained in this proposal can be used to develop a model for operation of the kinesin machine.
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