Biopsychosocial and Immunologic Responses to Battering

描述：亲密伴侣暴力(IPV)具有显著的长期影响 关于女性？S健康。尽管不断发现感染增加， 免疫功能的评估是当前研究中最薄弱的领域之一。 在压力反应框架内概念化对虐待的反应 心理健康对下丘脑-垂体-肾上腺(HPA)轴的影响 Th1/Th2细胞调节可能有助于解释IPV的影响 对免疫功能的影响。这项预测性相关性研究的主要目的 目的是：(1)确定在医院接受护理的妇女中IPV的流行率 马里兰州巴尔的摩未参保者诊所；(2)确定 有免疫功能的抑郁和创伤后应激障碍症状； 以及(3)识别免疫调节的预测因子。所有出席的女性 诊所的护理人员将完成一份简短的健康问卷，包括 滥用评估屏幕。IPV筛查呈阳性的合格女性 将邀请一个对照小组参加。量化数据来自 面谈和病历审查将评估伴侣虐待、抑郁/创伤后应激障碍 症状和健康问题；血清Th1(干扰素-7)和Th2(IL-10)水平 通过皮质醇调节的细胞因子将评估免疫系统 调制。将使用卡方、ANCIVA和ANCOVA技术来确定 心理健康症状与免疫功能的关系。多重 Logistic回归将调查TH1/Th2细胞调节的预测因素。 这项拟议的研究将有助于了解IPV的影响和 心理健康症状对免疫功能的影响。

DESCRIPTION: Intimate partner violence (IPV) has significant long-term effect on women?s health. In spite of persistent findings of increased infections, assessment of immune function is one of the weakest areas of current research. Conceptualizing the response to abuse within a stress response framework linking mental health effects on hypothalamic-pituitary-adrenal (HPA) axis regulation with Thl/Th2 cell modulation may help to explain the impact of IPV on immune function. The major purposes of this predictive correlational study are to: (1) identify the prevalence of IPV in women who receive care at a clinic for the uninsured in Baltimore, MD.;(2) to identify the relationship of depressive and post-traumatic stress disorder symptoms with immune function; and (3) to identify predictors of immune modulation. All women who present for care at the clinic will complete a brief health questionnaire including the Abuse Assessment Screen. Eligible women who screen positive for IPV along with a comparison group will be invited to participate. Quantitative data from interviews and medical chart review will assess partner abuse, depressive/PTSD symptoms, and health problems; serum levels of Thl (IFN-7) and Th2(IL-10) cytokines, which are mediated through cortisol, will assess immune system modulation. Chi-square, ANCIVA, and ANCOVA techniques will be used to determine the relationship of mental health symptoms and immune function. Multiple logistic regression will investigate predictors of TH1/Th2 cell modulation. This proposed study will contribute information on the effects of IPV and mental health symptoms on immune function.