Development of olivocerebellar interactions

这项研究计划将解决橄榄小脑系统内相互作用如何成熟的基本问题。将提出两个一般性问题：1)小脑和下橄榄生理发育差异的来源是橄榄小脑系统内动态相互作用的产物吗？2)发育差异是否完全依赖于神经成熟，还是可以通过加强某些区域的差异而减轻其他区域的差异来改变？本实验将利用神经生理学和药理学方法来阐明相对不成熟的大鼠幼鼠（出生后17-18天）和相对成熟的大鼠幼鼠（出生后24-25天）在体感信息处理方面的差异。橄榄小脑系统内的发育将在小脑皮层、小脑深部核区和下橄榄区观察到。橄榄小脑皮层、小脑深核和下橄榄相互作用的发展。橄榄小脑系统相互作用的发展将通过1)检查下橄榄成熟对小脑神经元活动的影响，以及2)检查小脑对下橄榄的影响来研究。这个项目可能会导致更好地理解与各种影响神经系统的发育障碍相关的功能病理学，包括胎儿酒精综合征、暴露于环境毒素和婴儿自闭症。

This research proposal will address the fundamental issue of how the interactions within the olivocerebellar system mature. Two general questions will be asked: 1) Are the sources of developmental differences in cerebellar and inferior olivary physiology a product of dynamic interactions within the olivocerebellar system? 2) Are the developmental differences completely dependent on neural maturation, or can they be changed by strengthening the differences in some areas and mitigating the differences in others? The experiments will use neurophysiology and pharmacology to elucidate the differences in somatosensory information processing between relatively immature rat pups (postnatal days 17-18) and relative mature rat pups (postnatal days 24-25). Development within the olivocerebellar system will be observed in the cerebellar cortex, the cerebellar deep nucleic, and the inferior olive. The development of interactions in the olivocerebellar cortex, the cerebellar deep nuclei, and the inferior olive. The development of interactions in the olivocerebellar system will be investigated by 1) examining the maturation of the inferior olive's influence on cerebellar neuronal activity, and 2) examining the influence that the cerebellum has on the inferior olive. This project may lead to a better understanding of the functional pathology associated with various developmental disorders that affect the nervous system including fetal alcohol syndrome, exposure to environmental toxins, and infantile autism.