Development of olivocerebellar interactions

橄榄小脑相互作用的发展

• 批准号: 6540466
• 负责人: DANIEL A NICHOLSON
• 金额: $ 2.25万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-10 至 2003-04-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6540466
• 关键词: afferent nerve; association learning; central neural pathway /tract; cerebellar Purkinje cell; cerebellum; conditioning; developmental neurobiology; immature animal; laboratory rat; mossy fiber; neural information processing; neural plasticity; neurogenesis; olivary body; synapses

This research proposal will address the fundamental issue of how the interactions within the olivocerebellar system mature. Two general questions will be asked: 1) Are the sources of developmental differences in cerebellar and inferior olivary physiology a product of dynamic interactions within the olivocerebellar system? 2) Are the developmental differences completely dependent on neural maturation, or can they be changed by strengthening the differences in some areas and mitigating the differences in others? The experiments will use neurophysiology and pharmacology to elucidate the differences in somatosensory information processing between relatively immature rat pups (postnatal days 17-18) and relative mature rat pups (postnatal days 24-25). Development within the olivocerebellar system will be observed in the cerebellar cortex, the cerebellar deep nucleic, and the inferior olive. The development of interactions in the olivocerebellar cortex, the cerebellar deep nuclei, and the inferior olive. The development of interactions in the olivocerebellar system will be investigated by 1) examining the maturation of the inferior olive's influence on cerebellar neuronal activity, and 2) examining the influence that the cerebellum has on the inferior olive. This project may lead to a better understanding of the functional pathology associated with various developmental disorders that affect the nervous system including fetal alcohol syndrome, exposure to environmental toxins, and infantile autism.

这项研究计划将解决橄榄小脑系统内的相互作用如何成熟的基本问题。两个一般性的问题将被问到：1）小脑和下橄榄生理发育差异的来源是橄榄小脑系统内动态相互作用的产物吗？2)发展差异是否完全依赖于神经成熟，或者可以通过加强某些区域的差异并减轻其他区域的差异来改变它们？这些实验将使用神经生理学和药理学来阐明相对不成熟的大鼠幼仔（出生后17-18天）和相对成熟的大鼠幼仔（出生后24-25天）之间体感信息处理的差异。在小脑皮质、小脑深核和下橄榄核中观察到橄榄小脑系统内的发育。橄榄小脑皮质、小脑深核和下橄榄相互作用的发展。橄榄小脑系统中相互作用的发展将通过以下方式进行研究：1）检查下橄榄的成熟对小脑神经元活动的影响，2）检查小脑对下橄榄的影响。这个项目可能会导致更好地理解与影响神经系统的各种发育障碍相关的功能病理学，包括胎儿酒精综合征，暴露于环境毒素和婴儿自闭症。