AGING AND INHIBITORY BEHAVIOR: AN FMRI STUDY

衰老和抑制行为：FMRI 研究

• 批准号: 6369996
• 负责人: ALLYSON C ROSEN
• 金额: $ 4.73万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-10-20 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6369996
• 关键词: age difference; aging; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; circadian rhythms; clinical research; cognition; developmental psychology; frontal lobe /cortex; functional magnetic resonance imaging; human subject; memory; neuropsychology; neuroregulation; psychological aspect of aging; questionnaires; saccades

The goal of the proposed studies is to use functional magnetic resonance imaging (fMRI) to identify brain regions corresponding to behaviorally observed inhibitory deficits in older adults. The critical question is whether there is one superordinate region or system which coordinates inhibitory behavior, such as the prefrontal lobes (West, 1996) or frontal-subcortical circuits (Alexander et al., 1986). Alternatively inhibition may be coordinated within each response modality and there is no overlapping superordinate system. It will be assumed that behavioral inhibition involves suppression of a prepotent/reflexive in favor of an intentional response. The first series of experiments will compare the overlap in functional activation for varied inhibitory tasks in young and elderly adults. The second experiments will test young and elderly adults under conditions which impair and facilitate inhibitory behavior, specifically at varying points in circadian the arousal cycle. The third experiment relates inhibitory behaviors to other cognitive processes by comparing subgroups of subjects that have been selected based on performance on a test of working memory functioning.

拟议研究的目标是使用功能磁共振成像（fMRI）来识别老年人行为观察到的抑制缺陷对应的大脑区域。关键的问题是，是否存在一个协调抑制行为的上级区域或系统，如前额叶（West, 1996）或额叶-皮层下回路（Alexander et al., 1986）。或者，抑制可以在每个反应模式中协调，并且没有重叠的上级系统。我们可以假设，行为抑制包括抑制优势性/反射性，以支持有意的反应。第一个系列的实验将比较不同的抑制任务在年轻人和老年人的功能激活重叠。第二个实验将测试年轻人和老年人在损害和促进抑制行为的条件下，特别是在昼夜节律觉醒周期的不同点。第三个实验将抑制行为与其他认知过程联系起来，通过比较根据工作记忆功能测试的表现选择的受试者分组。