Topical Estrogen/CB Patch for Wound Healing in Elderly

提出了一种外用雌激素贴片的开发，包括可生物降解的壳聚糖基生物聚合物（CB），以加速老年患者的伤口愈合。急性皮肤伤口愈合的延迟导致局部感染，伤口开裂，并过渡到慢性，不愈合的伤口。最近的临床数据显示，使用局部雌激素透皮贴片可以加速老年患者的伤口愈合。雌激素治疗的缺点之一是更大的疤痕形成。皮肤疤痕是一个主要的临床问题，涉及功能损害和限制生长。初步研究表明，在CB的存在下，成纤维细胞增殖增加。此外，据报道，CB可以减少体内疤痕的形成。在这个I期可行性研究中，我们建议：(1)在动物研究中检查局部雌激素/CB贴片对伤口愈合的比率和疤痕潜力；(2)通过初步的人体研究来证实动物数据。该应用程序的长期目标是开发一种雌激素贴片，以加速老年人的修复速度和愈合质量。建议的商业应用：局部雌激素贴片可能是一种可行的，加速老年人伤口愈合的治疗方法。此外，使用壳聚糖为基础的生物聚合物基质，显示减少疤痕形成，与雌激素一起，有望为伤口愈合应用提供比目前商业透皮雌激素贴片更好的选择。

The development of a topical estrogen patch including a biodegradable chitosan-based biopolymer (CB) to accelerate wound healing in the elderly patients is proposed. Delays in acute cutaneous wound healing lead to local infections, wound dehiscence, and a transition toward chronic, nonhealing wound. Recent clinical data have shown the benefit of using a topical estrogen transdermal patch to accelerate wound healing in elderly patients. One of the disadvantages of estrogen therapy is greater scar formation. Cutaneous scarring is a major clinical problem concerning functional impairment and restricted growth. Preliminary studies have shown increased fibroblast proliferation in the presence of CB. In addition, CB has been reported to reduce scar formation in vivo. In this Phase I feasibility study we propose: (1) to examine the rate and scarring potential of the topical estrogen/CB patch for wound healing in animal studies and (2) to confirm the animal data with preliminary human studies. The long-term goal of the proposed application is to develop an estrogen patch which accelerates the rate of repair as well as the quality of healing in the elderly. PROPOSED COMMERCIAL APPLICATIONS: A topical estrogen patch could be a viable, accelerated wound healing treatment in the elderly. In addition, the use of a chitosan-based biopolymer matrix showing reduced scar formation, together with the estrogen, is expected to provide a better alternative than current commercial transdermal estrogen patches for wound healing applications.