A NOVEL METAL-POLYMER COMPOSITE FOR AMALGAM REPLACEMENT

一种用于替代汞齐的新型金属聚合物复合材料

• 批准号: 6015247
• 负责人: Ivan Stangel
• 金额: $ 11.7万
• 依托单位: BIOMAT SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015247
• 关键词: adhesions; biomaterial development /preparation; composite resins; dental amalgam; dental implants; dental impression materials; microscopy; oral facial restoration material; polymers; spectrometry; surface coating

The use of dental amalgam for the reconstruction of teeth is controversial due to its release of mercury during in-service use. Thus, amalgam alternatives are frequently placed by dental practitioners. The most commonly used alternatives, ceramic reinforced polymer-matrix composites, have a survival rate that is approximately half that of amalgam. The purpose of this submission is to develop an alternative class of materials that can serve as a substitute for mercury-containing dental amalgam. Its successful development will lead to a cost-effective method of reconstructing diseased tooth tissue for the long-term using a mercury-free material. The specific aims of this research are to (1) synthesize polymerizable alkylthiols that can mediate strong bonds between metal fillers and polymers, (2) identify the optimal method of surface preparation of candidate substrates for the deposition of the alkylthiol, and (3) formulate prototype metal-polymer composites. The research design involves a synthesis phase where candidate compounds will be assessed for their ability to mediate strong bonds on models systems, the use of surface science techniques (spectroscopies, microscopies) to verify success of the synthesis as well as deposition of the compounds on candidate substrates, and the final phase where prototype materials will be mechanically characterized and assessed for their feasibility to be used as restorative materials for load-bearing surfaces of teeth. The potential for technological innovation is very positive. A core base of knowledge involving thiol chemistry and the ability of thiols to form dense, ordered monolayers on metals is used here. When functionalized with polymerizable vinyl groups, these compounds can strongly bind metal fillers to a polymer matrix and form an advanced material for dental use. PROPOSED COMMERCIAL APPLICATIONS: This research has several potential commercial applications. The first is in the field of oral health, where the successful development of a cost- effective, more durable alternative to dental amalgam is being sought. A second application involves the use of the adhesion promoters developed. These can act as couplers between metals and polymers for any biomedical application. They could be used for indirect restorative procedures in dentistry where metal appliances or single tooth restorations are bonded to enamel/dentin, or as bone cements in orthopedics when metal implants are used.

使用牙科汞合金进行牙齿重建是有争议的，因为它在使用过程中会释放汞。因此，牙科医生经常放置汞合金替代品。最常用的替代品是陶瓷增强聚合物基复合材料，其存活率约为汞合金的一半。本呈文的目的是开发一种替代材料，可作为牙科用含汞汞合金的替代品。该技术的成功开发将为长期使用无汞材料重建患病牙齿组织提供一种具有成本效益的方法。本研究的具体目的是（1）合成可聚合的烷基硫醇，可以介导金属填料和聚合物之间的强键，（2）确定最佳的表面制备方法的候选基板的烷基硫醇的沉积，和（3）制定原型金属-聚合物复合材料。研究设计包括一个合成阶段，在该阶段，将评估候选化合物在模型系统上介导强键的能力，（光谱学、显微镜学）以验证合成的成功以及化合物在候选基底上的沉积，在最后阶段，将对原型材料进行机械特性分析和评估，以确定其用作负载修复材料的可行性-齿的支承面。技术创新的潜力是非常积极的。知识的核心基础，涉及硫醇化学和硫醇的能力，形成致密的，有序的单层金属在这里使用。当用可聚合乙烯基官能化时，这些化合物可以将金属填料牢固地结合到聚合物基质上，并形成用于牙科的先进材料。建议的商业应用：这项研究有几个潜在的商业应用。第一个领域是口腔健康领域，该领域正在寻求成功开发一种成本效益高、更耐用的牙科汞合金替代品。第二种应用涉及使用所开发的粘合促进剂。它们可以作为金属和聚合物之间的耦合剂，用于任何生物医学应用。它们可用于牙科中的间接修复程序，其中金属器具或单齿牙釉质/牙本质粘合，或当使用金属植入物时作为骨科中的骨水泥。