DNA-peptide rotaxanes: Functional interlocked structures with biological components

轮烷和环己烷等超分子组装体被认为是发展合成分子机器的良好基础。当这些机器暴露在外部物理或化学输入时，可以使其执行工作(在轮烷的情况下，平移运动)。在这个项目中，我们将使用合成生物学来设计合适的生物构建块，以构建新型的连锁结构来控制平移运动和其他生物过程。

Supramolecular assemblies such as rotaxanes and catenanes are considered to be a good basis for the development of synthetic molecular machines. These machines could be made to perform work (in the case of rotaxanes, translational motion) when exposed to an external physical or chemical input. This motion can then be coupled to useful processes, such as data storage and transmission and chemical reactions.In this project, we will use synthetic biology to engineer suitable biological building blocks to construct novel interlocked structures for controlling translational motion and other biological processes.