CARCINOGENEIC SUBSTANCES AND HEALTH EFECTS OF ELECTMAGENTIC FIELDS

致癌物质和电磁场对健康的影响

• 批准号: 6494788
• 负责人: SISIR K DUTTA
• 金额: $ 13.19万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6494788
• 关键词: Clostridium; biotransformation; chemical carcinogen; chemical carcinogenesis; chemical related neoplasm /cancer; electric field; electromagnetic radiation; genetic library; halobiphenyl /halotriphenyl compound; high performance liquid chromatography; human genetic material tag; human tissue; magnetic field; nucleic acid hybridization; nucleic acid probes; nucleic acid sequence; polymerase chain reaction; radiation carcinogen; radiation carcinogenesis; radiation dosage; radiation genetics; radiation hazard; radiation related neoplasm /cancer; radiation sensitivity; radiobiology; tissue /cell culture

As an associate investigator the primary objectives of this subproject will be to provide motivation and training in human health effects of carcinogenic hazardous substances and electropollution (electric and magnetic field radiations) generated by electric power lines and cellular phones. Students will use latest state of the art tools in molecular genetic approaches. One undergraduate and three graduate students will b involved in the ongoing funded biomedical projects of Dr. S.K. Dutta. Graduate students, current working in the MBRS project will continue their studies for 2 to 4 years. Undergraduate students will be expected to continue their studies for 15 to 24 months. Students will be trained in library studies, in collection and in analysis of data for presentations in meetings and write manuscripts for publications. The involvement of students will be in the following three currently funded areas: (i) One graduate and one undergraduate student will participate in rhizosphere bioremediation of contaminated soil and drinking water which are contaminated by the explosive TNT (trinitrotoluene) and its toxic metabolites; (ii) One graduate student will be involved in isolation and characterization of 2-Am-4-DNT and 2,4- DNT genes from the white rot fungus Phanerochaete chrysosporium; (iii) One graduate student will be involved in phylogenetic and genome analysis of PCB dechlorinators. He/she will use ribotypes (based on 16S rRNA gene work) enriched from different contaminated sites and under different conditions having abilities to dechlorinate PCBs (polychlorobiphenyls). The fourth ongoing project has been to study possible carcinogenic effects of electric and magnetic fields generated by power lines and also be cellular phones. New funding for this fourth area is being solicited. Thus each student will have ideal environments for learning and be a productive biomedical scientist which is the major thrust of the current MBRS Associate Investigator program objectives. Several graduate and undergraduate MBRS students from Dr. Dutta's projects have received competitive monetary awards and plaques as recognitions for their quality research given by several national societies such as American Society for Microbiology, American Biophysical Society and Sigma Xi, as well as by Howard University Graduate School Symposium. Students have presented numerous papers in national meetings and are co-authors in serval papers.

作为副研究员，这一分项目的主要目标 将提供激励和培训对人类健康的影响 致癌危险物质和电污染(电和 磁场辐射)由电力线和蜂窝 电话。学生将使用最先进的分子工具 遗传方法。一名本科生和三名研究生将获得 参与了S.K.杜塔博士正在进行的资助生物医学项目。 研究生们，目前在MBRS项目工作的学生们将继续他们的 学习2至4年。本科生将被期望 继续学习15至24个月。学生们将接受关于 图书馆研究，收集和分析用于演示的数据 参加会议并为出版物撰写稿件。 学生的参与目前将有以下三个方面 资助领域：(I)1名毕业生和1名本科生 参与污染土壤的根际生物修复和 被爆炸性TNT污染的饮用水 (三硝基甲苯)及其有毒代谢物；(二)一名研究生 将参与2-AM-4-DNT和2，4-DNT的分离和鉴定 来自白腐菌Phanerochaete chrysosporium的dnt基因；(Iii)一个 研究生将参与系统发育和基因组分析 多氯联苯脱氯剂。他/她将使用核型(基于16S rRNA基因 工作)从不同的污染场地和在不同的 有能力脱氯多氯联苯(多氯联苯)的条件。 正在进行的第四个项目是研究可能的致癌效应。 由电力线产生的电场和磁场，也可以 手机。正在为这第四个领域争取新的资金。因此， 每个学生都将拥有理想的学习环境，成为富有成效的 生物医学科学家，这是目前MBR的主要推动力 助理调查员计划目标。 几名来自杜塔博士项目的研究生和本科生 获得了具有竞争力的金钱奖励和奖牌，以表彰 他们的高质量研究是由几个国家协会提供的，例如 美国微生物学会、美国生物物理学会和西格玛 以及霍华德大学研究生院研讨会。学生 在国家会议上发表了大量论文，并与人合著了 Serval文件。