MINIATURE BLOOD CELL COUNTER FOR NEUROLOGICAL DISORDERS

用于神经系统疾病的微型血细胞计数器

• 批准号: 6311390
• 负责人: Raghu Lehdar
• 金额: $ 17.54万
• 依托单位: LEHDAR SYSTEMS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6311390
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood cell count; electrical property; fluid flow; miniature biomedical equipment; nerve injury; nervous system disorder; stroke

DESCRIPTION: (Applicant's abstract) Many clinical/medical conditions, i.e, neurological emergencies and disorders, require rapid intervention. Stroke is one example. In this context, availability of medical devices can enhance medical care to the patient. Blood cell counters, which are used to count blood components such as red and white blood cells, are ubiquitous in medicine as a diagnostic aid for disease identification or as a general tool for many medical therapies. The pre-eminent device in use today is the Coulter counter, which is expensive, large, and generally not portable, requiring at least a desktop, household current supply and a small support laboratory. The goal of this research and development project is to design a prototype miniature blood cell counter for home-care, or point-of-care analysis in doctors' offices, clinics, and hospitals. The novel blood counter we propose to develop is based on new, emerging micromachine technologies, and would be approximately the size of a small cell-phone, requiring very low electrical power. Similar to an inkjet print head, which is also a product of micromachined fluidics technology, the core analytical components of the miniature blood counter would be inexpensively mass-produced. The cost per unit would be low enough that the analytical portion could here placed after each use. PROPOSED COMMERCIAL APPLICATION: The proposed device has several likely economic advantages. Firstly, it will reduce the need for and cost of transport of blood samples to centralized laboratory. Secondly, expedient diagnosis will mean fewer clinical complications fewer office visits, shorter hospital stays and possible a reduced need to transport patients. It could result in an overall savings of several million dollars annually.

描述：（申请人摘要）许多临床/医学状况，即， 神经系统紧急情况和疾病，需要迅速干预。中风是 一个例子。在这种情况下，医疗设备的可用性可以提高 对病人进行医疗护理。 血细胞计数器，用于计数血液成分，如红细胞和 白色血细胞，在医学上作为疾病的诊断辅助手段是普遍存在的 鉴定或作为许多医学治疗的通用工具。杰出的 今天使用的设备是库尔特计数器，它昂贵，大， 一般不便携，至少需要一个台式家用电源 和一个小型辅助实验室这项研究和开发的目标是 项目是设计一个原型微型血细胞计数器的家庭护理，或 医生办公室、诊所和医院的即时分析。 我们建议开发的新型血液计数器是基于新的、新兴的 微机械技术，并将大约是一个小的大小， 手机，需要非常低的电力。类似于喷墨打印 头部，这也是微加工射流技术的产品，核心 微型血液计数器的分析部件将是廉价的 批量生产。单位成本将足够低， 每次使用后可以放置一部分。 拟定商业应用： 拟议的设备具有几个可能的经济优势。 首先，它将减少 将血样运送到中心实验室的需要和费用。 第二、 快速诊断意味着更少的临床并发症，更少的门诊，更短的 住院时间和可能减少运送病人的需要。 这可能会导致 每年节省数百万美元。