MINIATURE BLOOD CELL COUNTER FOR NEUROLOGICAL DISORDERS

用于神经系统疾病的微型血细胞计数器

• 批准号: 6485205
• 负责人: Raghu Lehdar
• 金额: $ 56.32万
• 依托单位: LEHDAR SYSTEMS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6485205
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood cell count; electrical property; fluid flow; miniature biomedical equipment; nerve injury; nervous system disorder; stroke

DESCRIPTION: (Applicant's abstract) Many clinical/medical conditions, i.e, neurological emergencies and disorders, require rapid intervention. Stroke is one example. In this context, availability of medical devices can enhance medical care to the patient. Blood cell counters, which are used to count blood components such as red and white blood cells, are ubiquitous in medicine as a diagnostic aid for disease identification or as a general tool for many medical therapies. The pre-eminent device in use today is the Coulter counter, which is expensive, large, and generally not portable, requiring at least a desktop, household current supply and a small support laboratory. The goal of this research and development project is to design a prototype miniature blood cell counter for home-care, or point-of-care analysis in doctors' offices, clinics, and hospitals. The novel blood counter we propose to develop is based on new, emerging micromachine technologies, and would be approximately the size of a small cell-phone, requiring very low electrical power. Similar to an inkjet print head, which is also a product of micromachined fluidics technology, the core analytical components of the miniature blood counter would be inexpensively mass-produced. The cost per unit would be low enough that the analytical portion could here placed after each use. PROPOSED COMMERCIAL APPLICATION: The proposed device has several likely economic advantages. Firstly, it will reduce the need for and cost of transport of blood samples to centralized laboratory. Secondly, expedient diagnosis will mean fewer clinical complications fewer office visits, shorter hospital stays and possible a reduced need to transport patients. It could result in an overall savings of several million dollars annually.

描述：(申请人摘要)许多临床/医学状况，即， 神经性紧急情况和紊乱需要快速干预。中风是 一个例子。在这种情况下，医疗器械的可用性可以提高 对病人的医疗护理。 血细胞计数器，用于计算血液成分，如红血球和 白血球在医学上普遍存在，是疾病的辅助诊断工具。 识别或作为许多医疗疗法的通用工具。最杰出的 今天使用的设备是库尔特计数器，它昂贵、大和 通常不能携带，至少需要台式机、家用电源 和一个小型辅助实验室。这项研究和开发的目标是 项目是设计一个用于家庭护理的微型血细胞计数器的原型，或 医生办公室、诊所和医院的看护点分析。 我们计划开发的新型血液计数器是基于新出现的 微机械技术，并将大约是一个小的大小 手机，需要很低的电力。类似于喷墨打印机 磁头，这也是微机械流体技术的产品核心 微型血液计数器的分析部件将是廉价的 批量生产的。单位成本将低到足以使分析性的 每次使用后，可在此放置部分。 建议的商业应用： 拟议中的设备具有几个可能的经济优势。首先，它将减少 将血液样本运送到中央实验室的需要和费用。第二， 方便的诊断将意味着更少的临床并发症，更少的办公室就诊，更短的时间 住院时间和可能减少运送病人的需求。这可能会导致 每年总共节省几百万美元。