APOLIPOPROTEIN B VARIATION AND CORONARY HEART DISEASE RISK IN AFRICAN AMERICANS

非洲裔美国人的载脂蛋白 B 变异与冠心病风险

• 批准号: 6470088
• 负责人: Edward J Smith
• 金额: $ 11万
• 依托单位: TUSKEGEE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2002-09-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6470088
• 关键词: African American; adult human (21+); apolipoprotein B; atherosclerosis; atomic absorption spectrometry; blood lipoprotein; body weight; cardiovascular disorder epidemiology; clinical chemistry; clinical research; coronary disorder; disease /disorder proneness /risk; gene environment interaction; gene expression; gene frequency; genetic polymorphism; genotype; human middle age (35-64); human population study; human subject; immunoelectrophoresis; lifestyle; patient /disease registry; polymerase chain reaction; quantitative trait loci; statistics /biometry

A general consensus of numerous epidemiological studies is that altered plasma lipoprotein levels is a significant risk factor for the incidence and severity of cardiovascular diseases (CHD). Apolipoproteins (apo). structural components of lipoproteins. have also been described as risk factors for CHD. As a ligand for the low density lipoprotein (LDL)- receptor, apo B is of strong interest as an atherogenic factor. This interest has led to several investigations of the effect of apo B gene polymorphism on ligand and lipoprotein levels in several ethnic groups including Caucasians, Japanese, Chinese and Nigerians. In the present project we will test the hypothesis that genetic variation in apo B affects variability in plasma quantitative traits in African Americans. Specific activities will be conducted to test the hypothesis include: 1. Establish a registry consisting of 2000 randomly selected unrelated African American subjects between the ages of 18 and 65 who are residents of 12 Black Belt counties in Alabama; 2. Collect data on the study participants in the registry: Risk factors for CHD including lip, lipoprotein, apolipoprotein levels: other demographic variable including age, gender, weight, height, and other life style characteristics: 3. Determine within the individuals in the registry, the distribution of apo B haplotypes defined by recombinant DNA analysis: and 4. Conduct statistical analysis of the impact of apo B on lipid and lipoprotein levels in African Americans from the black-belt counties of Alabama. The results of the proposed work will provide evidence as to the impact of apo B gene polymorphism on difference in plasma risk factors for CHD in African Americans. As an incentive for participation, participants will receive nutritional education intervention using the Pen-3 Model to reduce the risk of developing CHD or, if already present effects of the disease. The work will also provide evidence necessary to determine if previously published reports of the significance of apo B as a CHD risk factor in Nigerian blacks can be extended to American blacks. The registry of individuals from the 12 Black Belt counties in Alabama will provide a useful resource for scientists interested in cohort studies of CHD and other diseases in African Americans.

许多流行病学研究的普遍共识是， 血浆脂蛋白水平是一个重要的危险因素， 和心血管疾病（CHD）的严重程度。载脂蛋白（apo）。 脂蛋白的结构成分。也被描述为风险 CHD的因素。作为低密度脂蛋白（LDL）的配体- 受体，载脂蛋白B作为致动脉粥样硬化因子受到强烈关注。这 人们对apo B基因作用的兴趣已经引起了一些研究 几个民族配体和脂蛋白水平的多态性 包括高加索人、日本人、中国人和埃塞俄比亚人。本 我们将检验载脂蛋白B的遗传变异 影响非裔美国人血浆数量性状的变异性。 具体的活动将进行测试的假设包括：1。 建立一个由2000名随机选择的无关 年龄在18岁至65岁之间的非裔美国人受试者， 亚拉巴马的12个黑带县; 2.收集研究数据 登记研究中的参与者：CHD的风险因素，包括唇， 脂蛋白、载脂蛋白水平：其他人口统计学变量，包括 年龄、性别、体重、身高等生活方式特征：3. 确定在登记的个体中，apo的分布 通过重组DNA分析确定的B单倍型;和4.进行 载脂蛋白B对血脂及脂蛋白影响的统计学分析 来自亚拉巴马黑带县的非裔美国人的水平。 拟议工作的结果将提供证据，说明 载脂蛋白B基因多态性与冠心病危险因素的关系 非裔美国人为了鼓励参与，参与者将 采用Pen-3模式进行营养教育干预， 发展CHD的风险，或者如果已经存在疾病的影响。 这项工作还将提供必要的证据，以确定是否以前 已发表的关于载脂蛋白B作为冠心病危险因素的重要性的报告， 尼日利亚黑人可以扩展到美国黑人。书记官处 来自亚拉巴马12个黑带县的个人将提供一个 对CHD队列研究感兴趣的科学家的有用资源， 非裔美国人的其他疾病。