Excitation Enhanced Ultrasound Contrast Imaging

激发增强超声对比成像

• 批准号: 6337458
• 负责人: RICHARD Bruce BERNARDI
• 金额: $ 30.51万
• 依托单位: SPECTRASONICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337458
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; blood flow measurement; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; contrast media; myocardial infarction; myocardial ischemia /hypoxia; perfusion; technology /technique development

DESCRIPTION (Provided by Applicant): This project proposes the development of a new technique for improving the performance of medical ultrasound systems using microbubble-based contrast agents. The ultimate goal is the creation of an "excitation enhanced" imaging system that will have a higher sensitivity than current ultrasound scanners. Vascular contrast agents are capable of enhancing the visibility of blood flow by several orders of magnitude. However their performance is still not sufficient to reliably image perfusion and diagnose conditions such as myocardial ischemia or infarction. The excitation enhanced ultrasound modality utilizes two acoustic fields: onefor contrast agent excitation and one for imaging. The excitation field temporarily increases the number of contrast agent bubbles with a size close to resonance at the frequency of the imaging field. If the imaging field is applied immediately after the excitation burst, acoustic scattering from the excited bubbles is markedly stronger than without the application of the excitation field. An in vitro system was constructed as part of the Phase I effort and experiments conducted using this system have demonstrated enhancements of up to 12dB. The next step is to modify an ultrasound scanner to include the modality and to validate the clinical potential of the technique with a series of in vivo experiments. PROPOSED COMMERCIAL APPLICATION: Ultrasonic Imaging is now the second most widely used imaging modality after x-ray. It's usage has increased in recent years due to the development of ultrasonic specific contrast agents. The proposed research will accelerate the usefulness of contrast aganets for many significant clinical applications.

描述(由申请人提供)：该项目建议开发一种 用于改善医用超声系统性能的新技术 微泡造影剂。最终目标是创建一个 “激发增强型”成像系统的灵敏度将高于 目前的超声波扫描仪。血管造影剂能够增强 血液流动的能见度提高了几个数量级。然而，他们的 性能仍然不足以可靠地进行图像灌注和诊断 心肌缺血或心肌梗死等情况。激励性增强 超声模式利用两个声场：一个用于造影剂 一个用于激发，一个用于成像。激励场暂时增加了 造影剂气泡的数量，其大小接近共振 成像场的频率。如果立即应用成像场 激发爆发后，激发气泡的声散射 明显强于没有施加激励场的情况。An In 作为第一阶段工作和实验的一部分，构建了体外系统 使用该系统进行的测试显示了高达12分贝的增强。这个 下一步是修改超声扫描仪，以包括医疗设备和 用一系列体内试验验证该技术的临床潜力 实验。 建议的商业应用： 超声成像现在是仅次于X射线的第二种最广泛使用的成像方式。近年来，由于超声特异性造影剂的发展，它的使用有所增加。这项拟议的研究将加速造影剂在许多重要临床应用中的应用。