Hybrid High Intensity Focused Ultrasound Transducer Development

混合高强度聚焦超声换能器的开发

• 批准号: 7272075
• 负责人: RICHARD Bruce BERNARDI
• 金额: $ 10万
• 依托单位: SPECTRASONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7272075
• 关键词: Abdomen; Acoustics; Animal Testing; Atrial Fibrillation; Cardiac ablation; Cardiovascular system; Ceramics; Characteristics; Coupling; Development; Elements; Facility Construction Funding Category; Focused Ultrasound Therapy; Generations; Goals; Heart Diseases; Hybrids; Image; Invasive; Kidney; Lesion; Liver; Measures; Medical; Operative Surgical Procedures; Organ; Pancreas; Performance; Phase; Physiologic pulse; Pulse taking; Research Subjects; Soft Tissue Disorder; System; Techniques; Technology; Testing; Tissues; Transducers; Ultrasonic Therapy; Ultrasonic Transducer; base; commercialization; copolymer; design; design and construction; imaging probe; improved; manufacturing process; polyvinylidene fluoride; programs; prototype; research and development; transmission process

DESCRIPTION (provided by applicant): A new type of HIFU (High Intensity Focused Ultrasound) linear array transducer, which is able to simultaneously function as a therapy as well as imaging probe, will be developed during this program. Contradictory acoustic requirements for imaging and therapy result in disparate piezoelectric material characteristics for each mode of operation. To overcome this difficulty a hybrid transducer design is proposed that will decouple the transmission operation from the receive function yet maintain coplanar imaging and therapy. The transducer will combine the use of a piezoelectric ceramic for therapy and pulse generation with a separate integral PVDF copolymer transducer for image reception. The transmitter uses the superior electromechanical coupling coefficient of piezoceramic materials to improve efficiency and reduce thermal problems during high power generation. By configuring a separate PVDF receiver one is able to obtain greater sensitivity and bandwidth during image reception. The goal of this program is to demonstrate improved dual use transducer capability by: 1) Constructing a single element hybrid transducer to produce high intensity acoustic field while functioning as a high performance A mode transducer 2) Designing an active clamping circuit to produce short imaging pulses for pulse echo reception 3) Constructing an elemental phased array to measure adequate array performance for both therapy and imaging. In the longer term Spectrasonics will utilize this transducer design for the development and commercialization of ultrasonically guided HIFU therapy systems for the minimally- invasive treatment of diseases of the heart, vascular and abdominal organs such as the liver, kidney and pancreas. For its initial focus Spectrasonics has chosen cardiac ablation for the treatment of Atrial Fibrillation. Ultrasound therapy has been the subject of research for many years, but it is only recently that this technique has found effective and widespread medical applications. High Intensity Focused Ultrasound (HIFU) is a noninvasive technique capable of selective destruction of tissue volumes within the body. HIFU is designed to ablate tissue (produce lesions) in the focal region of an acoustic beam in a predictable and reproducible manner This technology represents a major advance in image guided, minimally invasive therapy, and offer the potential to provide significant improvements in the treatment for a wide variety of soft tissue diseases.

描述（由申请人提供）：本项目将开发一种新型HIFU（高强度聚焦超声）线性阵列换能器，它能够同时用作治疗和成像探头。成像和治疗的矛盾的声学要求导致每种操作模式的压电材料特性不同。为了克服这一困难，提出了一种混合换能器设计，它将传输操作与接收功能解耦，同时保持共面成像和治疗。该换能器将用于治疗和脉冲生成的压电陶瓷与用于图像接收的单独集成PVDF共聚物换能器相结合。该发射器利用压电陶瓷材料优越的机电耦合系数来提高效率并减少高发电过程中的热问题。通过配置单独的 PVDF 接收器，人们能够在图像接收过程中获得更高的灵敏度和带宽。该计划的目标是通过以下方式展示改进的双用换能器功能：1) 构建单元件混合换能器以产生高强度声场，同时充当高性能 A 模式换能器 2) 设计有源钳位电路以产生用于脉冲回波接收的短成像脉冲 3) 构建基本相控阵以测量治疗和成像的足够阵列性能。从长远来看，Spectrasonics 将利用这种换能器设计来开发和商业化超声波引导 HIFU 治疗系统，以微创治疗心脏、血管和腹部器官（如肝脏、肾脏和胰腺）的疾病。 Spectrasonics 最初的重点是选择心脏消融术来治疗心房颤动。超声治疗多年来一直是研究主题，但直到最近，这项技术才发现有效且广泛的医学应用。高强度聚焦超声 (HIFU) 是一种非侵入性技术，能够选择性破坏体内的组织体积。 HIFU 旨在以可预测和可重复的方式消融声束聚焦区域的组织（产生病变）。该技术代表了图像引导微创治疗的重大进步，并有可能显着改进各种软组织疾病的治疗。