DEVELOPMENT OF A VIDEO TO TEACH THE LIFESKILLS WORKSHOP

修订后的第二阶段SBIR申请提出了与NIMH研究主题#l22B相关的研究和开发-“开发有效的录像带服务，旨在预防精神障碍和促进精神健康。”这项研究的长期目标是制作一盘录像带——“威廉姆斯生活技能录像带”——使病人和寻求健康的人能够减少心理社会风险因素（抑郁、焦虑、敌意和社会孤立），先前的研究表明，这些因素不仅会使他们自己感到痛苦，而且还会加速危及生命的医学疾病的发作和恶化预后。在我们的第一阶段研究中，我们开发并演示了本视频原型模块的可行性，该模块展示了八种生活技能之一的基本知识，断言。在这个第二阶段的申请中，我们建议开发和制作完整的11个模块的Williams LifeSkills视频，并评估其在减少社会心理风险因素和提高应对现实生活压力的能力方面的有效性，这些能力是由唾液皮质醇、静息血压和心率等生物标志物指标确定的。为此，我们将进行一项随机试验，其中至少有一种社会心理风险因素升高的社区志愿者被随机分为四组：l)等候名单对照组（N=50）；2)视频（N=50）；3) LifeSkills Workshop Only (N=7l)；或4)生活技能工作坊加视频（N=71）。心理社会风险因素和生物标志物将在3周干预前或等候期、干预后立即以及2个月和6个月随访时进行评估。我们预测，在急性和随访期间，视频单独和两种讲习班条件在减少心理社会风险因素方面优于等待名单，并且在六个月的随访中，讲习班加视频在维持效益方面优于讲习班。这项研究计划的成功完成将带来技术创新，使卫生保健提供者和预防计划能够以标准化、可重复和具有成本效益的方式提供人工培训，减少心理社会风险因素，改善心理健康和应对压力的能力。商业应用建议：对卫生保健组织中医疗保健高使用率者的需求管理，估计有500万患者，每年可能节省50亿美元。2. 公司健康/预防项目的潜在市场由美国和世界各地的数百家公司和政府机构组成（我们已经有两个合同）。

This revised Phase II SBIR application proposes research and development related to NIMH research topic #l22B - "Development of effective videotape services aimed at mental disorder prevention and mental health promotion." The long term objective of this research is to develop a videotape - the "Williams LifeSkills Video" - that will enable both patients and wellness seekers to reduce psychosocial risk factors (depression, anxiety, hostility, and social isolation) that prior research has shown to be not only distressing in themselves but also to hasten the onset and worsen the prognosis of life-threatening medical illnesses. In our Phase I research, we developed and demonstrated feasibility of a prototype module of this video that presents the basics of one of the eight LifeSkills, Assertion. In this application for a Phase II award, we propose to develop and produce the complete 11-module Williams LifeSkills video and evaluate its effectiveness in reducing psychosocial risk factors and improving the ability to cope with real life stress as indexed by the biomarkers salivary cortisol and resting blood pressure and heart rate. Toward this end, we will conduct a randomized trial in which community volunteers with an elevation of at least one psychosocial risk factor are randomized to one of four groups: l) Wait List control (N=50); 2) Video Only (N=50); 3) LifeSkills Workshop Only (N=7l); or 4) LifeSkills Workshop plus Video (N=71). Psychosocial risk factors and biomarkers will be assessed prior to 3-week intervention or wait list periods, immediately afterwards, and at two and six month follow-up. We predict the Video alone and both Workshop conditions will be superior to Wait List in reducing psychosocial risk factors acutely and during the follow-up period, and that the Workshop plus Video will be superior to Workshop Only in maintenance of benefits at six-month follow-up. Successful completion of this research program will result in technological innovation that enables health care providers and prevention programs to deliver - in standardized, reproducible and cost-effective manner - manualized training that reduces psychosocial risk factors and improves mental health and ability to cope with stress. PROPOSED COMMERCIAL APPLICATION: 1. Demand management for high utilizers of medical care in HMOs, estimated at 5 million patients with potential annual savings of $5 billion. 2. Corporate wellness/prevention programs with potential market composed of hundreds of corporations in the U.S. and worldwide and government agencies (where we already have two contracts).