DEVELOPMENT OF A VIDEO TO TEACH THE LIFESKILLS WORKSHOP

该修订的第二阶段SBIR申请提出了与NIMH研究主题#122B-“旨在预防精神障碍和促进精神健康的有效录像带服务的开发”相关的研究和开发。“这项研究的长期目标是开发一个录像带-“威廉姆斯生活技能视频”-这将使患者和寻求健康的人减少心理社会风险因素（抑郁，焦虑，敌意和社会孤立），以前的研究表明，这些因素不仅本身令人痛苦，而且会加速危及生命的医学疾病的发作和恶化预后。在我们的第一阶段研究中，我们开发并演示了该视频原型模块的可行性，该模块介绍了八项生活技能之一“断言”的基础知识。在申请第二阶段的奖励，我们建议开发和生产完整的11个模块的威廉姆斯生活技能视频和评估其有效性，减少心理社会风险因素和提高能力，以科普真实的生活压力的生物标志物唾液皮质醇和静息血压和心率。为此，我们将进行一项随机试验，其中至少有一种心理社会风险因素升高的社区志愿者被随机分为四组：1）等待名单对照组（N=50）; 2）仅视频组（N=50）; 3）仅生活技能研讨会（N= 71）;或4）生活技能研讨会加视频（N=71）。将在3周干预或等待期之前、之后立即以及2个月和6个月随访时评估心理社会风险因素和生物标志物。我们预测，单独使用视频和两种研讨会条件在急性和随访期间减少心理社会风险因素方面上级等待列表，并且研讨会加视频在6个月随访时的益处维持方面上级仅研讨会。这项研究计划的成功完成将导致技术创新，使医疗保健提供者和预防计划能够以标准化，可重复和具有成本效益的方式提供手动培训，减少心理社会风险因素，改善心理健康和科普压力的能力。建议的商业应用：1. HMO中医疗保健高利用者的需求管理，估计有500万患者，每年可能节省50亿美元。2.企业健康/预防计划，潜在市场由美国和全球数百家公司和政府机构组成（我们已经有两个合同）。

This revised Phase II SBIR application proposes research and development related to NIMH research topic #l22B - "Development of effective videotape services aimed at mental disorder prevention and mental health promotion." The long term objective of this research is to develop a videotape - the "Williams LifeSkills Video" - that will enable both patients and wellness seekers to reduce psychosocial risk factors (depression, anxiety, hostility, and social isolation) that prior research has shown to be not only distressing in themselves but also to hasten the onset and worsen the prognosis of life-threatening medical illnesses. In our Phase I research, we developed and demonstrated feasibility of a prototype module of this video that presents the basics of one of the eight LifeSkills, Assertion. In this application for a Phase II award, we propose to develop and produce the complete 11-module Williams LifeSkills video and evaluate its effectiveness in reducing psychosocial risk factors and improving the ability to cope with real life stress as indexed by the biomarkers salivary cortisol and resting blood pressure and heart rate. Toward this end, we will conduct a randomized trial in which community volunteers with an elevation of at least one psychosocial risk factor are randomized to one of four groups: l) Wait List control (N=50); 2) Video Only (N=50); 3) LifeSkills Workshop Only (N=7l); or 4) LifeSkills Workshop plus Video (N=71). Psychosocial risk factors and biomarkers will be assessed prior to 3-week intervention or wait list periods, immediately afterwards, and at two and six month follow-up. We predict the Video alone and both Workshop conditions will be superior to Wait List in reducing psychosocial risk factors acutely and during the follow-up period, and that the Workshop plus Video will be superior to Workshop Only in maintenance of benefits at six-month follow-up. Successful completion of this research program will result in technological innovation that enables health care providers and prevention programs to deliver - in standardized, reproducible and cost-effective manner - manualized training that reduces psychosocial risk factors and improves mental health and ability to cope with stress. PROPOSED COMMERCIAL APPLICATION: 1. Demand management for high utilizers of medical care in HMOs, estimated at 5 million patients with potential annual savings of $5 billion. 2. Corporate wellness/prevention programs with potential market composed of hundreds of corporations in the U.S. and worldwide and government agencies (where we already have two contracts).