DEVELOPMENT OF A VIDEO TO TEACH THE LIFESKILLS WORKSHOP

这一修订的第二阶段SBIR应用程序提出了与NIMH研究主题#122B-“旨在预防精神障碍和促进精神健康的有效录像带服务的发展”相关的研究和开发。这项研究的长期目标是开发一盘录像带--“威廉姆斯生活技能录像带”--使患者和寻求健康的人都能减少心理社会风险因素(抑郁、焦虑、敌意和社会孤立)，先前的研究表明，这些因素不仅本身令人痛苦，而且会加速危及生命的内科疾病的发生和恶化预后。在我们的第一阶段研究中，我们开发并演示了本视频的一个原型模块的可行性，该模块展示了八个生活技能之一的基础--断言。在第二阶段奖项的申请中，我们建议开发和制作完整的11个模块的Williams LifeSkills视频，并评估其在减少心理社会风险因素和提高应对现实生活压力能力方面的有效性，以唾液皮质醇和静息血压和心率为指标。为此，我们将进行一项随机试验，将具有至少一个心理社会危险因素的社区志愿者随机分为四组：L)轮候名单对照组(N=50)；2)仅视频(N=50)；3)仅生活技能研讨会(N=71)；或4)生活技能研讨会+视频(N=71)。心理社会危险因素和生物标记物将在3周干预或等待名单期间之前、紧接着之后以及在2个月和6个月的随访中进行评估。我们预测，在显著减少心理社会风险因素和后续期间，研讨会和两种研讨会的条件都将优于等待名单，而研讨会加视频将仅在六个月的随访中保持福利方面优于研讨会。成功完成这项研究计划将带来技术创新，使医疗保健提供者和预防计划能够以标准化、可重复和经济高效的方式提供手册培训，减少心理社会风险因素，改善心理健康和应对压力的能力。建议的商业应用：1.医疗保健服务的高利用率需求管理，估计有500万名患者，每年可能节省50亿美元。2.具有潜在市场的企业健康/预防计划，由美国和世界各地的数百家公司和政府机构(我们在那里已经有两份合同)组成。

This revised Phase II SBIR application proposes research and development related to NIMH research topic #l22B - "Development of effective videotape services aimed at mental disorder prevention and mental health promotion." The long term objective of this research is to develop a videotape - the "Williams LifeSkills Video" - that will enable both patients and wellness seekers to reduce psychosocial risk factors (depression, anxiety, hostility, and social isolation) that prior research has shown to be not only distressing in themselves but also to hasten the onset and worsen the prognosis of life-threatening medical illnesses. In our Phase I research, we developed and demonstrated feasibility of a prototype module of this video that presents the basics of one of the eight LifeSkills, Assertion. In this application for a Phase II award, we propose to develop and produce the complete 11-module Williams LifeSkills video and evaluate its effectiveness in reducing psychosocial risk factors and improving the ability to cope with real life stress as indexed by the biomarkers salivary cortisol and resting blood pressure and heart rate. Toward this end, we will conduct a randomized trial in which community volunteers with an elevation of at least one psychosocial risk factor are randomized to one of four groups: l) Wait List control (N=50); 2) Video Only (N=50); 3) LifeSkills Workshop Only (N=7l); or 4) LifeSkills Workshop plus Video (N=71). Psychosocial risk factors and biomarkers will be assessed prior to 3-week intervention or wait list periods, immediately afterwards, and at two and six month follow-up. We predict the Video alone and both Workshop conditions will be superior to Wait List in reducing psychosocial risk factors acutely and during the follow-up period, and that the Workshop plus Video will be superior to Workshop Only in maintenance of benefits at six-month follow-up. Successful completion of this research program will result in technological innovation that enables health care providers and prevention programs to deliver - in standardized, reproducible and cost-effective manner - manualized training that reduces psychosocial risk factors and improves mental health and ability to cope with stress. PROPOSED COMMERCIAL APPLICATION: 1. Demand management for high utilizers of medical care in HMOs, estimated at 5 million patients with potential annual savings of $5 billion. 2. Corporate wellness/prevention programs with potential market composed of hundreds of corporations in the U.S. and worldwide and government agencies (where we already have two contracts).