OUTCOME OF EXTRACELLULAR VOLUME CHANGE--THE OLDEST OLD

老年人患病态钠紊乱的患病率增加 和水的平衡。这是许多与年龄和疾病有关的次要症状。 生理动态平衡机制的改变 调节细胞外液的量和成分。要检查 细胞外体积增加对机体功能和功能的影响 荷尔蒙调节指数，我们正在研究健康的年轻人和老年人 志愿者的年龄从18岁到30岁不等，70岁以上。 在控制正常钠饮食三天后，每个人 志愿者接受24小时四小时心房采血 连续两次12小时尿钠尿肽水平(ANP) 以及运动试验，在运动试验期间，心钠素、加压素、 去甲肾上腺素水平与肺毛细血管的无创性评价 得到了楔形压力。这项研究大约重复了一次 一个月后，志愿者摄入250mEq(高)钠后 节食三天。数据分析将阐明两者之间的关系 中老年人的内分泌、心血管和肾脏系统 当盐的摄入量从正常到高变化时，久坐的志愿者。 心钠素分泌和钠排泄的年龄差异 小组也将接受检查。

The elderly suffer an increased prevalence of morbid disorders of sodium and water balance. This is secondary to many age and disease related alterations in the underlying physiologic homeostatic mechanisms regulating extracellular fluid volume and composition. To examine the influence of increased extracellular volume on physical functioning and hormonal regulatory indices, we are studying healthy young and old volunteers ranging in age from 18 to 30 years and 70 years and older. After eating a controlled normal sodium diet for three days, each volunteer undergoes 24 hours of four-hourly blood sampling for atrial natriuretic peptide level (ANP), two consecutive 12-hour urine collections, and an exercise test, during which ANP, vasopressin, norepinephrine levels and non-invasive estimation of pulmonary capillary wedge pressures are obtained. The study is repeated approximately a month later after the volunteer has consumed a 250 mEq (high) sodium diet for three days. Data analysis will elucidate the relationship among the endocrine, cardiovascular and renal systems of young and old sedentary volunteers when salt intake is varied from normal to high. Diurnal variation of ANP secretion and sodium excretion between age groups will also be examined.