OUTCOME OF EXTRACELLULAR VOLUME CHANGE--THE OLDEST OLD

细胞外体积变化的结果--最古老的老人

• 批准号: 6308057
• 负责人: KENNETH L. MINAKER
• 金额: $ 0.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308057
• 关键词: age difference; aging; atrial natriuretic peptide; blood chemistry; blood pressure; body fluids; circadian rhythms; clinical research; dietary sodium; electrolyte balance; exercise; functional ability; hormone regulation /control mechanism; human old age (65+); human subject; human very old age (85+); norepinephrine; pulmonary circulation; urinalysis; vasopressins; young adult human (21-34)

The elderly suffer an increased prevalence of morbid disorders of sodium and water balance. This is secondary to many age and disease related alterations in the underlying physiologic homeostatic mechanisms regulating extracellular fluid volume and composition. To examine the influence of increased extracellular volume on physical functioning and hormonal regulatory indices, we are studying healthy young and old volunteers ranging in age from 18 to 30 years and 70 years and older. After eating a controlled normal sodium diet for three days, each volunteer undergoes 24 hours of four-hourly blood sampling for atrial natriuretic peptide level (ANP), two consecutive 12-hour urine collections, and an exercise test, during which ANP, vasopressin, norepinephrine levels and non-invasive estimation of pulmonary capillary wedge pressures are obtained. The study is repeated approximately a month later after the volunteer has consumed a 250 mEq (high) sodium diet for three days. Data analysis will elucidate the relationship among the endocrine, cardiovascular and renal systems of young and old sedentary volunteers when salt intake is varied from normal to high. Diurnal variation of ANP secretion and sodium excretion between age groups will also be examined.

老年人患病疾病的患病率增加 和水平衡。这是许多年龄和疾病的继发 基础生理稳态机制的改变 调节细胞外流体体积和成分。检查 细胞外容量增加对身体功能的影响 荷尔蒙调节指数，我们正在研究健康的年轻人和老年人 志愿者的年龄从18至30岁及70岁及以上的志愿者不等。 吃了受控的正常钠饮食三天后，每次 志愿者经历24小时的四小时血液采样以进行心房 亚钠肽水平（ANP），两次连续12小时尿液 收集和运动测试，在此期间ANP，加压素， 去甲肾上腺素水平和肺毛细管的非侵入性估计 获得楔形压力。该研究重复大约 志愿者消耗250 MEQ（高）钠后一个月后 饮食三天。数据分析将阐明关系 在内分泌，年轻人和老年人的心血管和肾脏系统中 久坐的志愿者当盐的摄入量从正常到高。 年龄之间ANP分泌和钠排泄的昼夜变化 也将检查小组。