Elucidating the dynamics and antibiotic target potential of the bacterial cellular division complex by advanced microscopy

关键词：医疗技术，生物物理学，新型成像技术摘要：迫切需要新型抗菌素来对抗抗生素耐药性的上升。由于病原体现在已经对所有已知种类的抗生素产生耐药性，因此开发具有独特作用模式（MOA）的新型化合物至关重要。我们将利用先进的显微镜技术开发新的表型读数来解决这个问题，从而能够快速筛选新的MOAs，重点关注细菌细胞分裂抑制剂，这是一个关键的抗菌靶点。

Keywords: Healthcare technologies, biophysics, novel imaging technologiesAbstract: Novel antimicrobials are urgently required to combat the rise of antibiotic resistance. Because pathogens have now evolved resistance to all known classes of antibiotic, the development of novel compounds with unique mode of action (MOA) is crucial. We will to solve this problem by leveraging advanced microscopy to develop new phenotypic readouts which enable rapid screening for novel MOAs, focussed on inhibitors of bacterial cell division, a key antimicrobial target.