Elucidating the dynamics and antibiotic target potential of the bacterial cellular division complex by advanced microscopy

通过先进显微镜阐明细菌细胞分裂复合物的动力学和抗生素靶点潜力

• 批准号: 1792226
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1792226
• 关键词: Elucidating; dynamics; antibiotic; target; potential

Keywords: Healthcare technologies, biophysics, novel imaging technologiesAbstract: Novel antimicrobials are urgently required to combat the rise of antibiotic resistance. Because pathogens have now evolved resistance to all known classes of antibiotic, the development of novel compounds with unique mode of action (MOA) is crucial. We will to solve this problem by leveraging advanced microscopy to develop new phenotypic readouts which enable rapid screening for novel MOAs, focussed on inhibitors of bacterial cell division, a key antimicrobial target.

保留字：医疗保健技术，生物物理学，新型成像technologiesAbstract：新的抗菌药物迫切需要打击抗生素耐药性的上升。由于病原体现在已经进化出对所有已知类别抗生素的抗性，因此开发具有独特作用模式（MOA）的新型化合物至关重要。我们将通过利用先进的显微镜来开发新的表型读数来解决这个问题，这些读数能够快速筛选新型MOA，重点是细菌细胞分裂的抑制剂，这是一个关键的抗菌靶标。