SERUM AMINO ACID CONCENTRATIONS & NUTRITION IN CHILDREN W/ SICKLE CELL DISEASE

血清氨基酸浓度

• 批准号: 6305035
• 负责人: Peter Lane
• 金额: $ 1.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305035
• 关键词: African American; aminoacid metabolism; child (0-11); child physical development; clinical research; developmental nutrition; diet; essential aminoacid; human data; human subject; nutrient bioavailability; nutrition related tag; sickle cell anemia; urinalysis

Growth retardation and delayed pubertal maturation are commonly seen in children with sickle cell disease. Recent evidence suggests that African children with sickle cell disease are under-nourished, have hypoaminoacidemia and a significant loss of essential amino acids in the urine compared with healthy controls. We propose to evaluate the role of urinary excretion of amino acids and hypoaminoacidemia in the growth retardation and poor nutritional status of American children with sickle cell disease.

在患有镰状细胞病的儿童中，通常会出现迟滞和青春期成熟的延迟。 最近的证据表明，与健康对照组相比，非洲镰状细胞疾病疾病的儿童养育不足，患有低氨基酸血症，尿液中必需氨基酸的必需氨基酸显着丧失。 我们建议评估氨基酸和低氨基酸血症在生长迟缓和美国儿童患有镰状细胞病的营养状况不佳的作用。