GENETICS OF AUTISM

自闭症是儿童时期最有效的神经精神障碍之一， 可能代表多种致病因素的最终共同结果。 遗传似乎起到了重要作用：有一个自闭症孩子的家庭 面临后续儿童100倍以上的复发风险 人口风险。最近对双胞胎的研究表明，60岁到60岁之间 90%的同卵双胞胎与自闭症是一致的，而在 异卵双胞胎，符合率为零。总而言之，这些数据 强烈支持这一假设，即自闭症是由强烈的 不是绝对的，基因影响。犹他州自闭症项目旨在 通过研究可能的遗传和非遗传亚群确定自闭症的遗传亚群 疾病的表现和常见的传播量 自闭症儿童及其一级家庭的这些表现 会员。这一发现将与中国的对照组家庭进行对比。 先证者患有非特异性精神发育迟滞或 有阅读障碍。要测量的特征包括免疫能力， 认知，精神病学，形态差异，最后，变量 通过磁共振成像研究检测到的大脑。

Autism, one of the best validated neuropsychiatric disorders of childhood, may represent the final common outcome of multiple causative factors. Heredity appears to play an important role: families with one autistic child face a recurrence risk for subsequent children that is 100 times greater than the population risk. Recent studies of twins show that between 60 and 90% of identical twin pairs are concordant for autism, whereas in non-identical twins, the concordance rate is zero. Together, these data strongly support the hypothesis that autism results from a strong, thought not absolute, genetic influence. The Utah Autism Program Project aims to identify genetic and non-genetic subgroups of autism by studying possible manifestations of the disorder and the familiar amount of transmission of these manifestations in autistic children and their first-degree family members. The findings will be contrasted to control groups of families in which a proband has been affected with a nonspecific mental retardation or with dyslexia. Features to be measured include immunologic competence, cognitive, psychiatric, morphologic differences and finally, variables in the brain detected by magnetic resonance imaging studies.