Planning the Utah Center of Excellence for Autism

规划犹他州自闭症卓越中心

• 批准号: 6475265
• 负责人: William M McMahon
• 金额: $ 18.75万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6475265
• 关键词: autism; biomedical registry /referral center; child mental disorders; child mental health service; clinical research; education evaluation /planning; electroencephalography; health care service planning; health education; health science research; health services research tag; human subject; magnetic resonance imaging; magnetoencephalography; mental disorder diagnosis; mental health facility; neuroimaging; training

DESCRIPTION (Provided by applicant): Autism can be considered a prototype for neuropsychiatric developmental disorders. Diagnosis of autism has improved over the past 5 decades but still is based on developmental history and behavioral assessment, not on the underlying brain abnormality. The best current treatments for children with autism are directed at improving language, adaptive and social skills but do not address the biological basis of this disorder. Major advances in understanding the developmental neurobiology and genetics of autism may allow effective psychopharmacology and other biological treatments. Future recognition of the genetic and environmental factors contributing to the causation will allow for programs of prevention of autism and related developmental disorders. In parallel, programs to increase and improve training and to refine case identification and community awareness must be implemented to satisfy an immediate and growing need for diagnosis and treatment. Such progress will require a focused and synergistic effort by basic and clinical scientists in Centers of Excellence. The University of Utah proposes to develop such a Center over the next year. This application builds on a history of outstanding research in autism in Utah. Unique resources include a genealogical database, head circumference and structural neuroimaging findings for autism and a record of successful human gene discovery and genomics. The developmental plan for this Center includes three specific aims. First, we will develop working relationships, procedures and projects that integrate investigators at the University of Utah and Brigham Young University in basic and clinical disciplines relevant to autism research. Second, we will organize University and Department of Health and Mental Health resources into a Center of Excellence for autism research, diagnosis, referral and training. Finally, we will carry out pilot studies that develop promising research components in genetics, structural neuroimaging.

描述（由申请人提供）：自闭症可以被认为是一个原型， 神经精神发育障碍自闭症的诊断已经改善了， 但仍然是基于发展历史和行为 评估，而不是潜在的大脑异常。当前最佳的 对自闭症儿童的治疗是针对改善语言， 适应和社会技能，但不解决这一生物学基础 disorder.在理解发育神经生物学方面的主要进展， 自闭症的遗传学可能允许有效的精神药理学和其他生物学 治疗。未来对遗传和环境因素的认识 有助于因果关系将允许预防自闭症的计划 和相关的发育障碍。与此同时，增加和 改进培训和改进病例识别和社区认识，必须 实施以满足对诊断的即时和不断增长的需求， 治疗要取得这种进展，就需要基础部门作出有重点的协同努力， 和卓越中心的临床科学家。犹他州大学 他说，他计划在明年建立这样一个中心。此应用程序构建 关于犹他州自闭症杰出研究的历史。独特资源 包括家谱数据库、头围和结构神经成像 自闭症的发现和人类基因发现的成功记录， 基因组学该中心的发展计划包括三个具体目标。 首先，我们将发展工作关系、程序和项目， 整合了犹他州大学和杨百翰大学的研究人员 与自闭症研究相关的基础和临床学科。二是 组织大学和卫生与心理健康部的资源， 自闭症研究、诊断、转诊和培训卓越中心。 最后，我们将开展试点研究，发展有前途的研究 遗传学和结构神经成像的组成部分。