CORE--BIOMODEL

以施赖伯博士为主任的这一科学核心将是 负责内部所有项目通用的服务 程序。所有核心服务将通过DR申请。 Schreiber将批准此类请求。这些服务的集中化 将同时带来程序效率和成本效益。 CORE将负责1)分离、培养和分发 细胞培养和用于细胞培养的试剂制备2)固定， 细胞和组织样本的包埋、切片和固定3) 进行原位杂交，以及4)协助开发 转基因/敲除小鼠。此外，共聚焦激光扫描 显微镜(CLSM)将被所有项目使用，将由 个人调查人员，但这将由核心支付， 还将提供CLSM咨询服务和6)核心将发挥主要作用 在项目间的协作实验中发挥作用。下面是每个核心 服务描述的数字包括对核心的简要描述 设施和人员，将进一步详细说明适当的 表格。

This scientific core with Dr. Schreiber as director will be responsible for services that are common to all projects within the program. All core services will be requested by requisition through Dr. Schreiber who will approve such requests. Centralization of these services will lead to both procedural efficiency as well as cost efficiency The core will be responsible for 1)isolation, culturing and distribution of cell cultures and reagent preparation for cell cultures 2) fixing, embedding, sectioning and mounting of cell and tissue samples 3) performing in situ hybridizations, and 4) assisting in developing transgenic/knock out mice. In addition, 5) confocal laser scanning microscopy (CLSM) which will be used by all projects, will be performed by the individual investigators but it will be paid for by the core which will also offer CLSM consulting services and 6) the core will play a major role in collaborative experiments between projects. Below, each core service is described a number including a brief description of core facilities and personnel, which are detailed further on the appropriate forms.