CORE--BIOMODEL

这个以 Schreiber 博士为主任的科学核心将是 负责范围内所有项目通用的服务 程序。所有核心服务将通过 Dr. 申请。 施赖伯将批准此类请求。这些服务的集中化 将带来程序效率和成本效率 核心将负责1）分离、培养和分配 细胞培养物和细胞培养物的试剂制备2)固定， 细胞和组织样本的包埋、切片和封固 3) 进行原位杂交，4) 协助开发 转基因/基因敲除小鼠。另外，5）共焦激光扫描 所有项目都将使用的显微镜（CLSM）将由 个别调查员，但费用将由核心支付 还将提供 CLSM 咨询服务，6) 核心将发挥主要作用 在项目之间的协作实验中的作用。下面，每个核心 服务被描述了一些，包括核心的简要描述 设施和人员，进一步详细说明适当的 形式。

This scientific core with Dr. Schreiber as director will be responsible for services that are common to all projects within the program. All core services will be requested by requisition through Dr. Schreiber who will approve such requests. Centralization of these services will lead to both procedural efficiency as well as cost efficiency The core will be responsible for 1)isolation, culturing and distribution of cell cultures and reagent preparation for cell cultures 2) fixing, embedding, sectioning and mounting of cell and tissue samples 3) performing in situ hybridizations, and 4) assisting in developing transgenic/knock out mice. In addition, 5) confocal laser scanning microscopy (CLSM) which will be used by all projects, will be performed by the individual investigators but it will be paid for by the core which will also offer CLSM consulting services and 6) the core will play a major role in collaborative experiments between projects. Below, each core service is described a number including a brief description of core facilities and personnel, which are detailed further on the appropriate forms.