CORE--BIOMODEL

这个由Schreiber博士担任主任的科学核心将 负责所有项目的共同服务， 程序.所有核心服务将通过Dr. 画外音谁会批准这样的请求。这些服务的集中 将带来程序效率和成本效率。 核心将负责1）隔离，培养和分配 细胞培养物和用于细胞培养物的试剂制备2）固定， 细胞和组织样品的包埋、切片和封片3） 进行原位杂交，以及4）协助开发 转基因/敲除小鼠。5）共焦激光扫描 所有项目都将使用的显微镜（CLSM）将由 但它将由核心支付， 还将提供CLSM咨询服务，6）核心将发挥主要作用， 在项目间的合作实验中发挥作用。下面，每个核心 服务描述了一个数字，包括核心的简要说明 设施和人员，这是进一步详细的适当 forms.

This scientific core with Dr. Schreiber as director will be responsible for services that are common to all projects within the program. All core services will be requested by requisition through Dr. Schreiber who will approve such requests. Centralization of these services will lead to both procedural efficiency as well as cost efficiency The core will be responsible for 1)isolation, culturing and distribution of cell cultures and reagent preparation for cell cultures 2) fixing, embedding, sectioning and mounting of cell and tissue samples 3) performing in situ hybridizations, and 4) assisting in developing transgenic/knock out mice. In addition, 5) confocal laser scanning microscopy (CLSM) which will be used by all projects, will be performed by the individual investigators but it will be paid for by the core which will also offer CLSM consulting services and 6) the core will play a major role in collaborative experiments between projects. Below, each core service is described a number including a brief description of core facilities and personnel, which are detailed further on the appropriate forms.