Mouse Model Of Autistic Repetitive Behavior

自闭症重复行为小鼠模型

• 批准号: 6466297
• 负责人: Joseph Paul Garner
• 金额: $ 7.42万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-10 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6466297
• 关键词: autism; behavior test; behavioral /social science research tag; cognition; compulsive behavior; disease /disorder model; ethology; gamblings; laboratory mouse; model design /development; neuropsychological tests; videotape /videodisc

DESCRIPTION (provided by applicant): The presence of abnormal repetitive behaviors is necessary for a diagnosis of autism. These behaviors can be distressing, self-injurious, and difficult to treat. Despite their importance however, abnormal repetitive behaviors have received far less attention from researchers than other symptoms of autism. The specific goal of this project is therefore to develop an animal model of abnormal repetitive symptoms in autism. Abnormal repetitive behaviors in autistic patients are associated with disruption of 'executive' systems which are responsible for selecting and sequencing behavior. The performance of different executive systems can be measured using distinct neuropsychological tasks. Abnormal repetitive behavior in autism can be divided into 'high-level' behaviors which correlate with impairments in 'high-level' executive systems, measured using the IDED task; and 'low-level' behaviors which correlate with impairments in 'low-level' executive systems, measured using the gambling task. Abnormal repetitive behaviors commonly develop in captive animals. C57BL6/J laboratory mice perform two kinds - barbering (hair-pulling), and stereotypy - that closely resemble 'high-level' and 'low-level' behaviors respectively in autistic patients. If these behaviors are indeed equivalent to autistic symptoms they should correlate with the same measures of executive dysfunction. We will use a number of cognitive tasks, including the IDED and gambling tasks, to measure executive dysfunction in the mice. Our specific aims are therefore to: 1) develop standardized methods for recording these behaviors and performing these tasks in mice; 2) test the prediction that barbering will correlate with impairments on the IDED tasks; and 3) test the prediction that stereotypy will correlate with impairment on the gambling task. Developing a model of these symptoms in mice opens up several exciting new avenues for future research into environmental factors, genetic factors, and possible therapies.

描述（由申请人提供）：存在异常重复 行为是诊断自闭症的必要条件。这些行为可能是 令人痛苦，自我伤害，难以治疗。尽管他们的重要性， 然而，异常的重复行为受到的关注要少得多， 自闭症的其他症状。该项目的具体目标是 从而建立一种孤独症异常重复症状的动物模型。 自闭症患者的异常重复行为与 “执行”系统的中断，负责选择和 排序行为不同执行系统的性能可以 使用不同的神经心理学任务进行测量。异常重复行为 自闭症可以分为“高级”行为， 使用IDED任务测量的“高级”执行系统的损伤; 以及与"低水平"行为障碍相关的"低水平"行为 执行系统，使用赌博任务进行测量。异常重复 行为通常在圈养动物中发展。C57BL6/J实验室小鼠 两种-理发（拔头发）和刻板印象-非常类似 自闭症患者的"高水平"和"低水平"行为。如果 这些行为确实等同于自闭症症状， 与执行功能障碍的相同指标相关。我们将使用一个数字 认知任务，包括IDED和赌博任务，以衡量执行 小鼠的功能障碍。因此，我们的具体目标是：1）发展 记录这些行为和执行这些任务的标准化方法 在小鼠中; 2）测试理发与损伤相关的预测 3）测试刻板印象将与 在赌博方面有障碍开发这些症状的模型， 小鼠为未来的研究开辟了几条令人兴奋的新途径， 环境因素、遗传因素和可能的治疗方法。