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Neuropsychological Testing for Lupus and Depression

狼疮和抑郁症的神经心理学测试

基本信息

批准号：
6539286
负责人：
ELIZABETH KOZORA
金额：
$ 7.61万
依托单位：
NATIONAL JEWISH HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-20 至 2005-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6539286
关键词：
clinical research cognition disorders computer assisted diagnosis depression diagnosis design /evaluation disease /disorder classification fatigue human subject interview medical complication nervous system disorder diagnosis neuropsychological tests pain performance questionnaires sign /symptom statistics /biometry systemic lupus erythematosus

项目摘要

DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which is characterized by multi-system involvement and diverse manifestations. A large fraction of patients with SLE demonstrate organic psychiatric and neurologic disorders indicating central nervous system (CNS) involvement and the prevalence of cognitive abnormalities is approximatley 50 percent. An ad hoc multidisciplinary Committee of 35 members was convened by The American College of Rheumatology Research Committee in April of 1997 for the purpose of developing standard nomenclature for neuropsychiatric SLE and proposed a standard battery of neuropsychological tests for SLE This study was designed to provide validity and reliability for this proposed short battery. Pilot data by this investigator has suggested that diagnostic categories are complicated by a large proportion of systemic lupus erythematosus (SLE) patients being categorized as CNS-SLE (Central Nervous System-SLE) due to symptoms of depression. We see these preliminary data as providing controversy and ultimately opportunity to better classify and understand the cognitive effects of depression in SLE. Information regarding the sensitivity and specificity of this type of battery will justify the use of a short battery for clinical evaluation in SLE, in SLE patients with depression, and potentially in patients with depression only. Specific Aims are 1) To compare the frequency of neuropsychological impairment in CNS-SLE, CNS-SLE-depressed, non-CNSSLE and normal controls using the proposed American College of Rheumatology (ACR) Repeatable Neuropsychological Battery for SLE (ACR-RNB-SLE); 2) To examine the frequency of SLE patients impaired on the ACR-RNB-SLE compared to a larger comprehensive battery; 3) To determine reliability of the proposed ACR-RNB-SLE; 4) To examine associations between performance on the ACR-RNB-SLE and proposed measures of depression, fatigue and pain; and 5) To compare cognitive performance of the CNS-SLE-depressed group to a control group of depressed-only patients.

描述（由申请人提供）：系统性红斑狼疮（SLE）是一种以多系统受累为特征的慢性自身免疫性疾病和多种表现形式。大部分SLE患者表现出提示中枢神经系统的器质性精神和神经系统疾病 (CNS)参与和认知异常的患病率是大约50%。由35名成员组成的特设多学科委员会年由美国流变学研究委员会召集， 1997年4月，为制定标准命名法，神经精神系统性红斑狼疮，并提出了一个标准的电池的神经心理本研究旨在为SLE提供有效性和可靠性，这个提议的电池短路。该研究者的初步数据表明，诊断类别因大部分系统性狼疮而复杂化 SLE患者被归类为CNS-SLE（中枢神经系统疾病）系统性红斑狼疮）由于抑郁症的症状。我们将这些初步数据视为提供争议，并最终有机会更好地分类，了解抑郁症对SLE患者认知功能的影响。信息这种电池的灵敏度和特异性将证明使用 SLE临床评价的简短组合，在SLE患者中，抑郁症，并且可能仅在抑郁症患者中。具体的目标是 1)为了比较CNS-SLE中神经心理学损害的频率， CNS-SLE-抑郁，非CNSSLE和正常对照使用拟议的美国风湿病学院（ACR）SLE可重复神经心理成套测验（ACR-RNB-SLE）; 2）检查SLE患者在ACR-RNB-SLE上受损的频率， ACR-RNB-SLE与更大的综合电池相比; 3）确定建议的ACR-RNB-SLE的可靠性; 4）检查在ACR-RNB-SLE上的表现以及抑郁、疲劳和疼痛;和5）将CNS-SLE抑郁组的认知表现与对照组的抑郁症患者。