Neuropsychological Testing for Lupus and Depression

描述(申请人提供)：系统性红斑狼疮(SLE)是一种以多系统受累为特征的慢性自身免疫性疾病 和多样的表现形式。很大一部分SLE患者表现出 表明中枢神经系统的器质性精神和神经障碍 (CNS)受累和认知异常的患病率是 大约50%。由35名成员组成的特设多学科委员会 是由美国风湿病学会研究委员会于 1997年4月，为制定标准命名法的目的 并提出了一套标准的神经心理学标准 系统性红斑狼疮的测试这项研究旨在为 这个提议的短电池。这位调查员的试点数据表明， 诊断类别因很大比例的系统性红斑狼疮而变得复杂 红斑狼疮(SLE)患者被归类为CNS-SLE(中枢神经系统 系统-系统性红斑狼疮)由于抑郁症状。我们将这些初步数据视为 提供争议，并最终提供更好地分类和 了解抑郁症对系统性红斑狼疮的认知影响。有关以下信息： 这种类型的电池的灵敏度和特异度将证明使用 一种用于SLE临床评估的短电池，在SLE患者中 抑郁症，而且可能只存在于抑郁症患者中。具体目标是 1)比较CNS-SLE患者神经心理障碍的发生率， CNS-SLE-抑郁症、非CNSSLE和正常对照使用建议的美国 风湿病学院(ACR)治疗系统性红斑狼疮的可重复神经心理电池 (ACR-RNB-SLE)；2)检查SLE患者在 ACR-RNB-SLE与更大的综合电池进行比较；3)确定 建议的ACR-RNB-SLE的可靠性；4)检查 ACR-RNB-SLE的性能和抑郁、疲劳和建议的措施 5)比较中枢神经系统系统性红斑狼疮抑郁组与 一组单纯抑郁症患者的对照组。

DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which is characterized by multi-system involvement and diverse manifestations. A large fraction of patients with SLE demonstrate organic psychiatric and neurologic disorders indicating central nervous system (CNS) involvement and the prevalence of cognitive abnormalities is approximatley 50 percent. An ad hoc multidisciplinary Committee of 35 members was convened by The American College of Rheumatology Research Committee in April of 1997 for the purpose of developing standard nomenclature for neuropsychiatric SLE and proposed a standard battery of neuropsychological tests for SLE This study was designed to provide validity and reliability for this proposed short battery. Pilot data by this investigator has suggested that diagnostic categories are complicated by a large proportion of systemic lupus erythematosus (SLE) patients being categorized as CNS-SLE (Central Nervous System-SLE) due to symptoms of depression. We see these preliminary data as providing controversy and ultimately opportunity to better classify and understand the cognitive effects of depression in SLE. Information regarding the sensitivity and specificity of this type of battery will justify the use of a short battery for clinical evaluation in SLE, in SLE patients with depression, and potentially in patients with depression only. Specific Aims are 1) To compare the frequency of neuropsychological impairment in CNS-SLE, CNS-SLE-depressed, non-CNSSLE and normal controls using the proposed American College of Rheumatology (ACR) Repeatable Neuropsychological Battery for SLE (ACR-RNB-SLE); 2) To examine the frequency of SLE patients impaired on the ACR-RNB-SLE compared to a larger comprehensive battery; 3) To determine reliability of the proposed ACR-RNB-SLE; 4) To examine associations between performance on the ACR-RNB-SLE and proposed measures of depression, fatigue and pain; and 5) To compare cognitive performance of the CNS-SLE-depressed group to a control group of depressed-only patients.