TESTING INTERVENTIONS IN PEDIATRIC ASTHMA

描述（改编自申请人的描述）：该项目寻求 初步供资，以比较两种干预措施， 降低持续性哮喘儿童的发病率。最近的研究 表明哮喘儿童通常服用不到一半的 处方剂量的预防药物。针对这一问题 特别是有可能改善症状，降低发病率， 降低儿童哮喘的卫生保健利用率。 首先将进行焦点小组讨论，以提供有关初步 干预材料。然后，110个有一个孩子患有持续性哮喘的家庭 （8-14岁）将被招募到一个月的基线，包括电子 依从性评估，哮喘知识评估，自我效能评估， 发病率 在基线结束时，孩子表现出低于 70%的依从性（预期n = 60）将被随机分配至两组之一 治疗条件，行为反馈（BF）或哮喘教育 （AE）。 每次治疗包括三个个性化的一个小时的会议， 月的时间。 BF状况包括关于药物使用的反馈， 关于遵守障碍和行为契约的问题解决。 AE条件提供关于哮喘生物学和药物治疗的教育， 环境控制和症状评估和管理。坚持和 哮喘发病率将在干预月进行评估， 后处理。预计：1）EF条件下的参与者将 与AE受试者相比，依从性增加更大 条件和2）BF条件下的参与者将减少 相对于接受AE的受试者，哮喘导致的功能性发病率。 初步分析将确定相关协变量;关键分析将 确定组内和组间的干预效果。 探索性分析 将调查行为改变的媒介。 结果将用于设计 一项比较行为反馈与哮喘的大型随机对照试验 教育

DESCRIPTION (Adapted from applicant's description): This project seeks preliminary funding to compare two interventions to increase adherence and reduce morbidity for children with persistent asthma. Recent studies demonstrate that children with asthma typically take less than half of their prescribed doses of preventive medications. Targeting this problem specifically has the potential to improve symptoms, decrease morbidity, and decrease health care utilization in pediatric asthma. Focus groups will first be conducted to provide feedback regarding preliminary intervention materials. Then, 110 families with a child with persistent asthma (between 8-14) will be recruited into a month's baseline, including electronic adherence assessment, and evaluation of asthma know1edge, self-efficacy, and morbidity. At the end of baseline, families whose children exhibit less than 70% adherence (expected n equals 60) will be randomized to one of two treatment conditions, either Behavioral Feedback (BF) or Asthma Education (AE). Each treatment consists of three individualized one-hour sessions over a month's time. The BF condition includes feedback regarding medication use, problem-solving regarding adherence barriers, and behavioral contracting. The AE condition provides education regarding asthma biology and medications, environmental control, and symptom assessment and management. Adherence and asthma morbidity will be assessed during the intervention month, and one month post-treatment. It is expected that: 1) Participants in the EF condition will demonstrate greater increases in adherence than participants in the AE condition and 2) Participants in the BF condition will have decreased functional morbidity due to asthma relative to participants receiving AE. Preliminary analyses will determine relevant covariates; key analyses will determine intervention effects within and across groups. Exploratory analyses will investigate mediators of behavior change. Results will be used to design a larger, randomized controlled trial comparing behavioral feedback to asthma education.