JACKSON HEART STUDY--TRAINING CENTER

尽管心血管疾病（CVD）在过去三十年中出现了令人鼓舞的下降，但仍然是美国第一大死因。冠心病（CHD）和中风的许多危险因素已被确定；然而，相对较少的基于人群的研究对一大群非裔美国人的心血管疾病进行了调查。现有证据表明，密西西比州的死亡率是全国最高的，尤其是非裔美国人的死亡率最高。 1980 年至 1995 年间，密西西比州非裔美国男性和女性的 CVD 死亡率下降速度与该州和全国其他群体相比是最慢的。杰克逊心脏研究 (JHS) 是一项针对 CVD 的单中心前瞻性流行病学调查，研究对象为来自密西西比州杰克逊都会区的约 6,500 名 35 岁至 84 岁的非裔美国人。 JHS 的主要目标是调查非裔美国人 CVD 的原因，以了解未来如何最好地预防此类疾病。更具体的目标包括： (1) 确定影响非裔美国人 CVD 发生和恶化的因素，重点关注与高血压相关的表现（如左心室扩大、冠状动脉疾病、心力衰竭、中风和影响肾脏血管的疾病）。 (2) 通过发展少数群体和多数群体机构之间的伙伴关系以及加强少数群体研究人员参与大规模流行病学研究，建设少数群体机构本科生和研究生水平的研究能力。 (3) 让少数民族学生参与公共卫生和流行病学工作并为其做好准备。该项目作为协调中心，将管理研究期间收集的所有数据、进行数据分析并协调社区参与。

Despite encouraging declines over the past three decades, cardiovascular disease (CVD) remains the number one cause of death in the U.S. A number of risk factors for coronary heart disease (CHD) and stroke have been identified; however, relatively few population-based studies have examined CVD in a large group of African-Americans. Existing evidence indicated that death rates in Mississippi are the highest in the nation and particularly high among African-Americans. Between 1980 and 1995, the decline in CVD death rates has been the slowest among African-American men and women in Mississippi relative to other groups in the state and nation. The Jackson Heart Study (JHS) is a single-site prospective epidemiologic investigation of CVD among approximately 6,500 African-Americans ages 35 to 84, from Jackson, Mississippi metropolitan area. The primary objective of the JHS is to investigate the causes of CVD in African- Americans to learn how to best prevent this group of diseases in the future. More specific objectives include: (1) Identifying factors which influence the development and worsening of CVD in African-Americans, with an emphasis on Manifestations related to high blood pressure (such as enlargement of the left ventricle of the heart, coronary artery disease, heart failure, stroke and disorders affecting the blood vessels of the kidney). (2) Building research capabilities in minority institutions at the undergraduate and graduate level by developing partnerships between minority and majority institutions and enhancing participation of minority investigators in large-scale epidemiologic studies. (3) Attaching minority students to and preparing them for careers in public health and epidemiology. This project serves as the Coordinating Center where all data collected during the study will be managed, analysis of the data will be performed, and community involvement will be coordinated.