JACKSON HEART STUDY--TRAINING CENTER

尽管心血管疾病(CVD)在过去30年中出现了令人鼓舞的下降，但它仍然是美国头号死亡原因。已经确定了许多导致冠心病(CHD)和中风的危险因素；然而，相对较少的基于人群的研究检查了一大批非裔美国人中的CVD。现有证据表明，密西西比州的死亡率是全国最高的，尤其是在非裔美国人中。1980至1995年间，相对于该州和全国的其他群体，密西西比州非裔美国人男性和女性的心血管疾病死亡率下降最慢。杰克逊心脏研究(JHS)是一项针对来自密西西比州杰克逊市的大约6500名年龄在35岁至84岁的非裔美国人进行的关于心血管疾病的单一地点前瞻性流行病学调查。JHS的主要目标是调查非裔美国人心血管疾病的原因，以了解如何在未来最好地预防这类疾病。更具体的目标包括：(1)确定影响非裔美国人心血管疾病发展和恶化的因素，重点是与高血压有关的表现(如心脏左心室增大、冠状动脉疾病、心力衰竭、中风和影响肾脏血管的疾病)。(2)通过发展少数群体和多数群体机构之间的伙伴关系，加强少数群体研究人员对大规模流行病学研究的参与，在本科和研究生一级建设少数群体机构的研究能力。(3)培养少数族裔学生，并为他们从事公共卫生和流行病学工作做好准备。该项目作为协调中心，将管理研究期间收集的所有数据，对数据进行分析，并协调社区参与。

Despite encouraging declines over the past three decades, cardiovascular disease (CVD) remains the number one cause of death in the U.S. A number of risk factors for coronary heart disease (CHD) and stroke have been identified; however, relatively few population-based studies have examined CVD in a large group of African-Americans. Existing evidence indicated that death rates in Mississippi are the highest in the nation and particularly high among African-Americans. Between 1980 and 1995, the decline in CVD death rates has been the slowest among African-American men and women in Mississippi relative to other groups in the state and nation. The Jackson Heart Study (JHS) is a single-site prospective epidemiologic investigation of CVD among approximately 6,500 African-Americans ages 35 to 84, from Jackson, Mississippi metropolitan area. The primary objective of the JHS is to investigate the causes of CVD in African- Americans to learn how to best prevent this group of diseases in the future. More specific objectives include: (1) Identifying factors which influence the development and worsening of CVD in African-Americans, with an emphasis on Manifestations related to high blood pressure (such as enlargement of the left ventricle of the heart, coronary artery disease, heart failure, stroke and disorders affecting the blood vessels of the kidney). (2) Building research capabilities in minority institutions at the undergraduate and graduate level by developing partnerships between minority and majority institutions and enhancing participation of minority investigators in large-scale epidemiologic studies. (3) Attaching minority students to and preparing them for careers in public health and epidemiology. This project serves as the Coordinating Center where all data collected during the study will be managed, analysis of the data will be performed, and community involvement will be coordinated.