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HEMODYNAMIC EFFECTS OF DOBUTAMINE & MILRINONE

多巴酚丁胺的血流动力学效应

基本信息

批准号：
6425942
负责人：
E MICHAEL GILBERT
金额：
$ 0.16万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-12-01 至 1999-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6425942
关键词：
beta antiadrenergic agent clinical research cyclic AMP dobutamine drug interactions drug screening /evaluation gene expression heart disorder chemotherapy heart failure hemodynamics human subject human therapy evaluation idiopathic dilated cardiomyopathy pharmacokinetics phosphodiesterase inhibitors

项目摘要

This is a randomized, double-blind, parallel group, active-controlled trial of eighteen months' duration and a total of 72 patients. The study will be performed at two sites, the University of Utah GCRC and the University of Colorado GCRC. Patients with NYHA class II-IV heart failure due to idiopathic dilated cardiomyopathy will be treated with either bucindolol or metoprolol to determine changes in myocardial gene expression associated with either of these drugs. Changes in gene expression associated with alterations in myocardial function and remodeling are also under study. If bucindolol or metoprolol proves to lower cardiac adrenergic drive, then the relationship of this effect to changes in myocardial gene expression will be defined. If bucindolol or metoprolol lowers activity of the renin-angiotensin system, then the relationship of this effect will also be correlated with changes in myocardial gene expression. Milrinone is a phosphodiesterase inhibitor and the use of this agent will enable the investigators to determine if the effects of bucindolol are enhanced by this drug, suggesting that bucindolol may also act through a cyclic-AMP-dependent mechanism. This study is in its earliest phases but no data are mature enough to report.

这是一项为期18个月的随机、双盲、平行组、活性对照试验，共纳入72例患者。本研究将在两个研究中心（犹他州大学GCRC和科罗拉多大学GCRC）进行。特发性扩张型心肌病导致NYHA II-IV级心力衰竭的患者将接受布新洛尔或美托洛尔治疗，以确定与这两种药物相关的心肌基因表达变化。与心肌功能改变和重塑相关的基因表达变化也在研究中。如果布新洛尔或美托洛尔被证明降低心脏肾上腺素能驱动，那么这种作用与心肌基因表达变化的关系将被确定。如果布新洛尔或美托洛尔降低了肾素-血管紧张素系统的活性，那么这种作用的关系也将与心肌基因表达的变化相关。米力农是一种磷酸二酯酶抑制剂，使用这种药物将使研究人员能够确定布新洛尔的作用是否被这种药物增强，这表明布新洛尔也可能通过环AMP依赖性机制起作用。这项研究处于早期阶段，但没有足够成熟的数据可以报告。