INHIBITION OF CYTOKINE PRODUCTION/VIRAL REPLICATION ON BODY COMPOSITION

细胞因子产生/病毒复制对身体成分的抑制

• 批准号: 6305597
• 负责人: Kathleen Mulligan
• 金额: $ 0.06万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305597
• 关键词: AIDS therapy; HIV infections; antiAIDS agent; antiviral agents; basal metabolism; bioenergetics; body composition; body weight; clinical research; cytokine; human subject; human therapy evaluation; outcomes research; virus replication

Despite numerous anecdotal reports of increases in weight if patients who begin aggressive new antiretroviral regimens, the magnitude and composition of weight gain has not been studied rigorously. Moreover, there are no data on potential mechanisms by which these increases in weight might occur. This study is designed to evaluate the effects of inhibition of viral replication on weight, body composition, resting energy expenditure, and energy intake in patients who are initiating potent antiretroviral therapy at the direction of their physician.

尽管有许多轶事报道说，如果患者开始积极的新的抗逆转录病毒治疗，体重增加的幅度和组成还没有得到严格的研究。 此外，也没有数据说明体重增加的潜在机制。 本研究旨在评价在医生指导下开始强效抗逆转录病毒治疗的患者中抑制病毒复制对体重、身体组成、静息能量消耗和能量摄入的影响。