MANGANESE SUPEROXIDE DISMUTASE AND IN VIVO AGING

描述(改编自调查者摘要)：拟议的研究 将探讨我国对锰超氧化物歧化酶的要求 通过一些独特的突变模型进行衰老和组织损伤 果蝇。这些突变模型将被用来(1)研究 在不同组织中定向过表达MnSOD，检测 假设MnSOD在特定组织或细胞类型中过表达 通过提供更强的防氧化保护来延长寿命 (2)研究特定组织中MnSOD功能丧失的影响 或细胞类型，检验MnSOD功能丧失与 氧化应激增加，加速组织损伤；(3) 研究MnSOD基因错义突变的影响，检测 假设就像家族性肌萎缩侧索硬化症(FALS)患者一样， MnSOD活性改变可能导致神经病理和组织退变 损害赔偿。

DESCRIPTION (adapted from the Investigator's abstract): The proposed research will probe into the requirement of manganese-superoxide dismutase [MnSOD] in aging and tissue damages thereof through some unique mutant models in Drosophila. These mutant models will be used to (1) investigate the effect of overexpression of MnSOD in different tissues in a directed fashion, testing the hypothesis that overexpression of MnSOD in specific tissue or cell types extends the life span by offering increased protection against oxidative damage; (2) investigate the effect of loss of MnSOD function in specific tissue or cell types, testing the hypothesis that loss of MnSOD function is associated with increased oxidative stress causing accelerated tissue damages; (3) investigate the effects of missense mutations in MnSOD gene, testing the hypothesis that like in familial amyotrophic lateral sclerosis (FALS) patients, altered MnSOD activity could cause neuropathology and degenerative tissue damages.