DST and Suicide Prediction

夏令时和自杀预测

• 批准号: 6421853
• 负责人: ELIZABETH ANN YOUNG
• 金额: $ 28.42万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-25 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6421853
• 关键词: behavior prediction; behavioral /social science research tag; bipolar depression; clinical research; cortisol; dexamethasone suppression test; disease /disorder proneness /risk; gender difference; human data; human mortality; major depression; male; mental health information system; method development; psychometrics; suicide

DESCRIPTION (provided by applicant): Suicide is a major public health problem in the US. To date, the main risk factors identified in multiple clinical samples include male sex, living alone and suicidal ideation. Recent data suggest that demonstrating non-suppression to cortisol on the dexamethasone suppression test (DST) may be a more robust clinical predictor than these other variables. This is further supported by post-mortem data indicating chronic activation of the HPA axis such as increased adrenal weight and increased POMC mRNA in the anterior pituitary. Furthermore, strong evidence supports the effects of cortisol in modulating brain serotonin systems. This project depends upon the existence of a large database of subjects with the diagnosis of major depression who received the DST between 1978 and 1987. All subjects also received SADS interviews and weekly Ham-D ratings during assessment and follow-up. After identifying index cases, we will examine mortality rates particularly suicide in DST positive and negative subjects as well as examining the relationship between a number of other potential risk factors for suicide and completed suicide.

描述（由申请人提供）：自杀是一个主要的公共卫生问题 在美国.迄今为止，在多个临床研究中确定的主要风险因素 样本包括男性，独居及自杀意念。最近的数据 提示地塞米松对皮质醇无抑制作用 抑制试验（DST）可能是一个更强大的临床预测比这些其他 变量这一点得到了尸检数据的进一步支持， HPA轴激活，如肾上腺重量增加和POMC增加 垂体前叶的mRNA。此外，有力的证据支持 皮质醇在调节大脑血清素系统中的作用。这个项目取决于 在存在诊断为主要疾病的受试者的大型数据库时， 1978年至1987年间接受DST的抑郁症患者。所有科目也 在评估期间接受SADS访谈和每周Ham-D评分， 随访在确定指标病例后，我们将研究死亡率 特别是DST阳性和阴性受试者的自杀， 其他一些潜在的自杀风险因素之间的关系 完成了自杀