HPA AXIS FUNCTION, NEUROIMAGING & ESTROGEN AUGMENTATION IN DEPRESSED WOMEN

HPA 轴功能，神经影像

• 批准号: 6303484
• 负责人: ELIZABETH ANN YOUNG
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303484
• 关键词: antidepressants; brain imaging /visualization /scanning; clinical research; clinical trials; depression; estrogens; hormone therapy; human subject; hypothalamic pituitary adrenal axis; lymphocyte; opioid receptor; receptor expression; women's health

Activation of the stress axis is present in a number of patients with depression. In addition alterations in brain opioid receptors in depressed patients has been found by brain imaging. Both stress hormones and opioid receptors are involved in the regulation of reproductive axis hormones. In this study, we are interested in the links between these two biological systems and treatment response to a standard antidepressant, fluoxetine, and the effects of estrogen in altering the response to antidepressants. At baseline we will evaluate the stress axis with the use of metyrapone, and examine brain opioid receptors with [11C]-carfentanil by PET imaging. Following these studies, women will be enrolled in a 6 week trial of fluoxetine At the end of 6 weeks, individuals who have not fully responded to treatment, will be randomized to receive either estrogen augmentation or placebo for an additional 4 weeks.

压力轴的激活存在于许多抑郁症患者中。此外，通过脑成像发现抑郁症患者脑阿片受体的改变。应激激素和阿片受体都参与生殖轴激素的调节。在这项研究中，我们感兴趣的是这两个生物系统之间的联系和标准抗抑郁药氟西汀的治疗反应，以及雌激素在改变抗抑郁药反应中的作用。 在基线时，我们将使用甲吡酮评估应激轴，并通过PET成像检查[11 C]-卡芬太尼的脑阿片受体。 在这些研究之后，女性将被纳入为期6周的氟西汀试验。在6周结束时，对治疗没有完全反应的个体将被随机分配接受雌激素增加或安慰剂，再持续4周。