Bipolar Illness Therapy, Family Burden, Costs & Health

描述(申请人提供)：双相情感障碍是一种严重的， 以反复发作的抑郁和抑郁为特征的致残性精神障碍 躁狂，对健康、情感和经济福祉产生不利影响 帮助照顾病人的家庭成员。拟议的研究是 双相情感障碍系统治疗强化计划的辅助研究 障碍(STEP-BD)，其目的是测试家庭与 在这项临床试验中采用了基于个人的心理社会治疗来 减轻精神负担以及对健康和经济的不利影响 照顾患有急性躁狂症或抑郁症的亲属。它还声称要检查 在治疗过程中减轻负担对患者的影响 患者的临床结果。300人的主要家庭照顾者(PC) 被SCID诊断为双相或II型障碍的患者被选为参与 急性抑郁症或复发的随机临床路径 将根据家庭负担、健康和应对措施对预防进行评估： 1)治疗前；2)治疗后；3)6个月后。随机效果 回归模型将被用来检验差异效应的假设 家庭集中治疗(FFT)与个体化治疗的对比 强化心理治疗(认知、行为或人际社交节律 治疗)，或个人非强化心理教育：1)程度 双相情感障碍患者家属报告的负担 加班，以及2)与非正式护理相关的资源成本。结果是 将检查临床结果中一个重要的差异来源 不包括在STEP-BD协议中。他们将帮助我们理解家庭是如何 负担和应对对照顾者的健康和健康做法的影响 患有躁郁症的人。

DESCRIPTION (provided by applicant): Bipolar affective disorder is a severe, disabling mental disorder characterized by recurrent episodes of depression and mania, which impact adversely on the health, emotional and economic well-being of the family members that help care for the patient. The proposed research is an ancillary study to Systematic Treatment Enhancement Project for Bipolar Disorder (STEP-BD), which aims to test the effectiveness of the family vs. individually-based psychosocial treatments employed in this clinical trial to alleviate the emotional burdens and adverse health and economic effects of caring for relative with acute mania or depression. It also claims to examine the effects of reductions in burden over the course of treatment on the patients' clinical outcomes. The primary family caregivers (PC's) of 300 patients with SCID-diagnosed Bipolar or II Disorder selected to participate in the Randomized Clinical Pathways (RCP's) for Acute Depression or Relapse Prevention will be evaluated on measures of family burden, health and coping: 1) pre-treatment; 2) post-treatment; and 3) six months later. Random effects regression models will be used to test the hypothesis of a differential effect of treatment with family-focused therapy (FFT) vs. treatment with individual intensive psychotherapy (Cognitive Behavioral or Interpersonal Social Rhythms Therapy), or individual nonintensive psychoeducation on: 1) the degree of burden reported by the family members of patients with bipolar disorder overtime, and 2) the resource costs associated with informal care. The results of the study will examine an important source of variance in clinical outcome not included in the STEP-BD protocol. They will help us understand how family burden and coping impact on the health and health practices of caregivers of person with bipolar illness.