Bipolar Illness Therapy, Family Burden, Costs & Health

描述（由申请人提供）：双相情感障碍是一种严重的， 以反复发作的抑郁症为特征的致残性精神障碍， 躁狂症，对健康，情绪和经济福祉产生不利影响 帮助照顾病人的家庭成员。拟议的研究是 双极患者系统性治疗增强项目的辅助研究 障碍（STEP-BD），旨在测试家庭与 本临床试验中采用的基于个体的心理社会治疗， 减轻情绪负担和不利的健康和经济影响， 照顾患有急性躁狂症或抑郁症的亲属。它还声称要检查 在治疗过程中减轻负担对 患者的临床结果。300名主要家庭照顾者 选择参与研究的诊断为双相或II型情感障碍的SCID患者 急性抑郁症或复发的随机临床路径（RCP） 将根据家庭负担、健康和应对措施对预防进行评估： 1)治疗前; 2）治疗后; 3）6个月后。随机效应 回归模型将用于检验差异效应的假设 以家庭为中心的治疗（FFT）与个人治疗的比较 强化心理治疗（认知行为或人际社会节律 治疗），或个人非强化心理教育：1）程度 双相情感障碍患者家属报告的负担 加班费; 2）与非正式护理相关的资源成本。结果 将检查临床结果差异的重要来源 不包括在STEP-BD方案中。他们将帮助我们了解家庭 负担和应对方式对儿童照料者的健康和保健做法的影响 患有躁郁症的人

DESCRIPTION (provided by applicant): Bipolar affective disorder is a severe, disabling mental disorder characterized by recurrent episodes of depression and mania, which impact adversely on the health, emotional and economic well-being of the family members that help care for the patient. The proposed research is an ancillary study to Systematic Treatment Enhancement Project for Bipolar Disorder (STEP-BD), which aims to test the effectiveness of the family vs. individually-based psychosocial treatments employed in this clinical trial to alleviate the emotional burdens and adverse health and economic effects of caring for relative with acute mania or depression. It also claims to examine the effects of reductions in burden over the course of treatment on the patients' clinical outcomes. The primary family caregivers (PC's) of 300 patients with SCID-diagnosed Bipolar or II Disorder selected to participate in the Randomized Clinical Pathways (RCP's) for Acute Depression or Relapse Prevention will be evaluated on measures of family burden, health and coping: 1) pre-treatment; 2) post-treatment; and 3) six months later. Random effects regression models will be used to test the hypothesis of a differential effect of treatment with family-focused therapy (FFT) vs. treatment with individual intensive psychotherapy (Cognitive Behavioral or Interpersonal Social Rhythms Therapy), or individual nonintensive psychoeducation on: 1) the degree of burden reported by the family members of patients with bipolar disorder overtime, and 2) the resource costs associated with informal care. The results of the study will examine an important source of variance in clinical outcome not included in the STEP-BD protocol. They will help us understand how family burden and coping impact on the health and health practices of caregivers of person with bipolar illness.