DISCHARGE PATTERNS OF MOTONEURONS

运动神经元的放电模式

• 批准号: 6430409
• 负责人: PEDRO N RUDOMIN
• 金额: $ 15.2万
• 依托单位: CINVESTAV-IPN
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6430409
• 关键词: cats; central neural pathway /tract; cutaneous sensory nerve; dorsal horn; electrophysiology; inflammation; membrane potentials; motor neurons; nerve injury; neural conduction; neural inhibition; neuromuscular function; neuroregulation; sensorimotor system; sensory mechanism; somatic afferent nerve; synapses

DESCRIPTION (provided by applicant): The general objective of our research has been to understand the mechanisms and functional organization of the spinal pathways involved in the presynaptic control of the synaptic effectiveness of muscle, cutaneous and joint afferents and the role of these mechanisms in motor performance and sensory discrimination. One, perhaps the most attractive issue that has emerged from the studies we have performed during the last few years, is the finding of central mechanisms that produce a differential inhibition of the primary afferent depolarization (PAD) elicited in the intraspinal collaterals of individual muscle spindle afferents. This allows, at least in principle, a selective addressing of the information generated in the periphery to specific sets of neurons. One of the Specific Aims of this proposal is to analyze the extent to which the differential control of PAD observed in muscle and cutaneous afferents has any functional consequences on the postsynaptic responses elicited by these inputs in different sets of target neurons. Another, relatively unexplored aspect of the presynaptic control mechanisms, is its plasticity and adaptability in response to inflammation and peripheral nerve damage or conduction block. We now propose to study, in the anesthetized cat, the alterations in the presynaptic control of synaptic actions of joint afferents during acute inflammation of joints and skin, in view of pronounced changes in reflex actions caused by inflammatory processes, as well as the changes in the presynaptic control of transmission from cutaneous afferents following the unmasking of spinal reflexes caused by peripheral nerve damage or conduction block. We have shown recently that in the anesthetized cat there is a set spontaneously active dorsal horn neurons that modulates impulse transmission in several spinal pathways, including those mediating presynaptic inhibition of muscle and cutaneous afferents. We will now explore the functional organization of this set of neurons and some of the pathways and mechanisms that may be involved in the synchronization of their activity, and how this activity is modified by peripheral nerve damage and acute inflammation of the skin.

描述（由申请人提供）：我们研究的总体目标是 了解脊柱的机制和功能组织， 参与突触前控制的突触有效性的通路 肌肉、皮肤和关节传入以及这些机制在运动中的作用 性能和感官辨别力。一个，也许是最吸引人的问题 从我们过去几年的研究中得出的结论， 是发现产生差异抑制的中枢机制， 初级传入去极化（PAD）在椎管内 单个肌梭传入神经的侧支。这使得，至少在 原则，选择性地寻址在外围产生的信息 到特定的神经元该提案的具体目标之一是 分析在肌肉中观察到的PAD差异控制的程度 和皮肤传入神经对突触后神经元的功能影响 这些输入在不同的目标神经元中引起的反应。 突触前控制机制的另一个相对未被探索的方面是 它的可塑性和适应性，以应对炎症和外周 神经损伤或传导阻滞。我们现在建议研究，在麻醉的 猫，改变突触前控制的突触行动的关节 在关节和皮肤急性炎症的传入，鉴于明显的 炎症过程引起的反射动作的变化，以及 皮肤传入神经传递的突触前控制变化 在由周围神经损伤引起的脊髓反射暴露后，或 传导阻滞我们最近已经证明，在麻醉的猫中， 一组自发活动的背角神经元， 在几个脊髓通路，包括那些介导突触前 抑制肌肉和皮肤的传入。我们现在将探讨 这组神经元的功能组织和一些通路， 可能参与其活动同步的机制，以及 外周神经损伤和急性炎症如何改变这种活性 的皮肤。