DISCHARGE PATTERNS OF MOTONEURONS

运动神经元的放电模式

• 批准号: 6687765
• 负责人: PEDRO N RUDOMIN
• 金额: $ 15.35万
• 依托单位: CINVESTAV-IPN
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6687765
• 关键词: cats; central neural pathway /tract; cutaneous sensory nerve; dorsal horn; electrophysiology; inflammation; membrane potentials; motor neurons; nerve injury; neural conduction; neural inhibition; neuromuscular function; neuroregulation; sensorimotor system; sensory mechanism; somatic afferent nerve; synapses

DESCRIPTION (provided by applicant): The general objective of our research has been to understand the mechanisms and functional organization of the spinal pathways involved in the presynaptic control of the synaptic effectiveness of muscle, cutaneous and joint afferents and the role of these mechanisms in motor performance and sensory discrimination. One, perhaps the most attractive issue that has emerged from the studies we have performed during the last few years, is the finding of central mechanisms that produce a differential inhibition of the primary afferent depolarization (PAD) elicited in the intraspinal collaterals of individual muscle spindle afferents. This allows, at least in principle, a selective addressing of the information generated in the periphery to specific sets of neurons. One of the Specific Aims of this proposal is to analyze the extent to which the differential control of PAD observed in muscle and cutaneous afferents has any functional consequences on the postsynaptic responses elicited by these inputs in different sets of target neurons. Another, relatively unexplored aspect of the presynaptic control mechanisms, is its plasticity and adaptability in response to inflammation and peripheral nerve damage or conduction block. We now propose to study, in the anesthetized cat, the alterations in the presynaptic control of synaptic actions of joint afferents during acute inflammation of joints and skin, in view of pronounced changes in reflex actions caused by inflammatory processes, as well as the changes in the presynaptic control of transmission from cutaneous afferents following the unmasking of spinal reflexes caused by peripheral nerve damage or conduction block. We have shown recently that in the anesthetized cat there is a set spontaneously active dorsal horn neurons that modulates impulse transmission in several spinal pathways, including those mediating presynaptic inhibition of muscle and cutaneous afferents. We will now explore the functional organization of this set of neurons and some of the pathways and mechanisms that may be involved in the synchronization of their activity, and how this activity is modified by peripheral nerve damage and acute inflammation of the skin.

描述（由申请人提供）：我们研究的总体目标是 了解脊柱的机制和功能组织 参与突触前控制突触有效性的途径 肌肉、皮肤和关节传入神经以及这些机制在运动中的作用 表现和感官辨别。一、也许是最吸引人的问题 这是我们过去几年进行的研究得出的结果， 是发现产生差异抑制的中心机制 椎管内引起的初级传入去极化（PAD） 单个肌梭传入神经的侧络。这至少允许在 原理，对外围产生的信息进行选择性寻址 到特定的神经元组。该提案的具体目标之一是 分析肌肉中观察到的 PAD 差异控制程度 和皮肤传入神经对突触后有任何功能影响 这些输入在不同的目标神经元组中引起的反应。 突触前控制机制的另一个相对未被探索的方面是 其对炎症和外周反应的可塑性和适应性 神经损伤或传导阻滞。我们现在建议在麻醉状态下进行研究 cat，关节突触动作的突触前控制的改变 鉴于明显的关节和皮肤急性炎症期间的传入 炎症过程引起的反射动作的变化，以及 皮肤传入神经传递的突触前控制的变化 因周围神经损伤或引起脊髓反射暴露后 传导块。我们最近证明，麻醉猫体内存在 一组自发活动的背角神经元，调节冲动 多种脊髓通路的传递，包括介导突触前的通路 抑制肌肉和皮肤传入。我们现在将探讨 这组神经元的功能组织以及一些通路和 可能涉及其活动同步的机制，以及 这种活动如何因周围神经损伤和急性炎症而改变 皮肤的。