PREDNISONE & FISH OIL SUPPLEMENTS IN CHILDREN & YOUNG ADULTS W/ IGA NEPHROLOGY

强的松

• 批准号: 6303457
• 负责人: JOSEPH T FLYNN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303457
• 关键词: IgA nephropathy; child (0-11); clinical research; clinical trials; diet therapy; dietary supplements; hormone therapy; human subject; human therapy evaluation; kidney function; marine animal oil; nutrition related tag; prednisone; young adult human (21-34)

IgA nephropathy is a disease of the kidneys which leads to loss of blood and protein in the urine and can lead to severe kidney failure even when it begins in childhood. Unfortunately, there is no proven treatment for IgA nephropathy, although a few reports have described the successful treatment of patients with this condition with either fish oil supplements or a medication called prednisone. Those taking part will be asked to participate in a 5-year clinical trial which will compare every-other-day prednisone or daily fish oil capsules with a placebo (a pill which contains no medicine) in the treatment of my IgA nephropathy. The purpose of this study to be the evaluation of whether fish oil supplements or alternate-day prednisone can prevent or slow the decline in kidney function expected in children, adolescents and young adults with moderate to severe IgA nephropathy. Neither the doctor or patient will be told which one of the three treatments they are taking.

IgA肾病是一种肾脏疾病，它会导致尿液中血液和蛋白质的流失，甚至在儿童时期就开始导致严重的肾衰竭。不幸的是，目前还没有证实的治疗IgA肾病的方法，尽管有一些报道描述了用鱼油补充剂或强的松药物成功治疗这种疾病的患者。参与者将被要求参加一项为期5年的临床试验，该试验将比较每隔一天服用强的松或每日服用鱼油胶囊与安慰剂（一种不含药物的药丸）治疗我的IgA肾病的效果。本研究的目的是评估鱼油补充剂或隔日强的松是否可以预防或减缓患有中重度IgA肾病的儿童、青少年和年轻人的肾功能下降。医生和病人都不会被告知他们正在接受三种治疗中的哪一种。