VITAMIN E IN TREATMENT OF IGA NEPHROPATHY IN CHILDREN

目前，尚无临床证明有效的治疗IgA肾病的方法。这是一项多中心研究，患有活检证实的临床轻度IgA肾病的儿童和年轻人将随机接受维生素E或安慰剂每日治疗。在获得基线实验室数据并将受试者随机分组后，将在为期两年的时间内每四个月进行一次随访。在这些访问中将获得血液和尿液样本，每年将获得48小时的尿液收集。参与这项研究的风险很小，因为在研究中使用的剂量的维生素E没有有害影响。参与的好处是，如果治疗有效，维生素E接受者的IgA肾病可能会得到改善；对安慰剂接受者没有直接好处。希望这项研究的结果将导致对IgA肾病的有效治疗。

At present, there is no treatment for IgA Nephropathy that has been proven to be clinically effective. This is a multicenter study in which children and young adults with biopsy-proven, clinically mild IgA Nephropathy will be randomized to receive either Vitamin E or placebo daily. After baseline laboratory data has been obtained and the subject has been randomized, they will be seen in follow-up every four months for a period of two years. Blood and urine samples will be obtained at these visits, and a 48 hour urine collection will be obtained annually. Risk of participation in the study is minimal, as there are no harmful effects of Vitamin E at the doses to be used in the study. The benefit to participation is possible amelioration of IgA Nephropathy in Vitamin E recipients if the treatment is effective; there is no direct benefit to placebo recipients. It is hoped that the results of this study will lead to an effective treatment for IgA Nephropathy.