Effect of anti-IgE antibody on immune system responses and short-term outcome in acute asthma in children

抗 IgE 抗体对儿童急性哮喘免疫系统反应和短期结局的影响

• 批准号: nhmrc : 1087700
• 负责人: A/Pr Guicheng Zhang
• 金额: $ 38.12万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-anti-ige-asthma-children/519181
• 关键词: Effect; anti; IgE; antibody; immune

We plan to undertake a randomised, double-blind, placebo-controlled, clinical trial of anti-IgE antibody given at the time of an acute attack of asthma in children aged 6-12 years. The idea for this arose from our own novel data – IgE levels increase with the most common infection causing acute asthma. Given evidence the virus uses IgE to cause inflammation, giving anti-IgE during the attack should reduce the severity of the attack and produce a new, effective treatment for acute asthma.

我们计划进行一项随机、双盲、安慰剂对照的临床试验，在6-12岁儿童哮喘急性发作时给予抗IgE抗体。这一想法源于我们自己的新数据--IgE水平随着最常见的导致急性哮喘的感染而增加。鉴于有证据表明病毒利用IgE引起炎症，在发作期间给予抗IgE应该会减轻发作的严重性，并产生一种新的、有效的治疗急性哮喘的方法。