EFFECT OF CORTICOTROPHIN RELEASING HORMONE ON RELEASE OF ACTH & CORTISOL

促肾上腺皮质激素释放激素对 ACTH 释放的影响

• 批准号: 6307752
• 负责人: SUSAN SCOTT
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307752
• 关键词: adrenocorticotropic hormone; clinical research; corticotropin releasing factor; cortisol; human subject; infant human (0-1 year); premature infant human; respiratory distress syndrome of newborn; secretion

In the adult, there is potentiation of ACTH release with CRH challenge in the setting of severe illness. In our results, the ACTH test demonstrates that peak cortisol release is decreased in premature infants that have been ill during the first week of life, is greater in the 4 day old than the six day old infant. These results suggest that, unlike the adult where the HPA is activated during a state of illness, the ill premature infaants may not respond in this fashion and may be at-risk of low release cortisol.

在成人中，在严重疾病的情况下，CRH激发可增强ACTH的释放。 在我们的研究结果中，ACTH测试表明，在生命的第一周内生病的早产儿的皮质醇释放峰值降低，4天的婴儿比6天的婴儿更大。 这些结果表明，与HPA在疾病状态下被激活的成年人不同，患病的早产儿可能不会以这种方式做出反应，并且可能处于低释放皮质醇的风险中。