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MOLECULAR BASIS FOR DYSLEXIA IN KLINEFELTERS SYNDROME

MOLECULAR BASIS FOR DYSLEXIA IN KLINEFELTERS SYNDROME
克兰费尔特综合征阅读障碍的分子基础
批准号：
6306706
负责人：
JULIE RUTH KORENBERG
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6306706
关键词：
Klinefelter's syndrome behavior disorders clinical research dyslexia hormone therapy human subject human therapy evaluation hypogonadism learning disorders male molecular pathology neuropsychological tests testosterone

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英文摘要
The purpose of this research is to study to what degree patients with Klinefelter syndrome suffer from dyslexia and behavioral and learning disabilities and if testosterone replacement therapy alters these disabilities. Hypogonadal patients with Klinefelter syndrome undergo detailed neuropsychological testing before and after testosterone treatment. Men enrolled in the study also have blood drawn for the establishment of lymphoblastoid cell lines, with the goal being to examine genetic differences in the X chromosome to see if they impact on the occurrence and severity of the neuropsychological disabilities. This study capitalizes on synergy between the parent GCRC at Harbor-UCLA, where the patients are recruited and tested, and the Cedars-Sinai GCRC, where the lymphoblastoid cell lines are established.
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MOLECULAR GENETIC BASIS OF WILLIAM'S SYNDROME
A Computational Framework for Mapping Long Range Genetic Circuits
  • 批准号：
    7845097
  • 项目类别：
  • 资助金额：
    $49.68万
  • 财政年份：
    2009
  • 负责人：
    JULIE RUTH KORENBERG
  • 依托单位：
    UNIVERSITY OF UTAH
A Computational Framework for Mapping Long Range Genetic Circuits
  • 批准号：
    7938599
  • 项目类别：
  • 资助金额：
    $49.91万
  • 财政年份：
    2009
  • 负责人：
    JULIE RUTH KORENBERG
  • 依托单位：
    UNIVERSITY OF UTAH
MOLECULAR GENETIC BASIS OF WILLIAM'S SYNDROME
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