MOLECULAR BASIS FOR DYSLEXIA IN KLINEFELTERS SYNDROME

本研究的目的是研究Klinefelter综合征患者在多大程度上患有阅读障碍、行为和学习障碍，以及睾酮替代疗法是否能改变这些障碍。性腺功能低下的Klinefelter综合征患者在睾酮治疗前后接受详细的神经心理测试。参与这项研究的男性还需要抽血以建立淋巴母细胞样细胞系，目的是检查X染色体上的遗传差异，看看它们是否对神经心理残疾的发生和严重程度有影响。这项研究利用了Harbor-UCLA的亲本GCRC和Cedars-Sinai GCRC之间的协同作用，前者招募和测试了患者，后者建立了淋巴母细胞样细胞系。

The purpose of this research is to study to what degree patients with Klinefelter syndrome suffer from dyslexia and behavioral and learning disabilities and if testosterone replacement therapy alters these disabilities. Hypogonadal patients with Klinefelter syndrome undergo detailed neuropsychological testing before and after testosterone treatment. Men enrolled in the study also have blood drawn for the establishment of lymphoblastoid cell lines, with the goal being to examine genetic differences in the X chromosome to see if they impact on the occurrence and severity of the neuropsychological disabilities. This study capitalizes on synergy between the parent GCRC at Harbor-UCLA, where the patients are recruited and tested, and the Cedars-Sinai GCRC, where the lymphoblastoid cell lines are established.