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Synthetic biology approaches for the production of plant secondary metabolites in microalgae

在微藻中生产植物次生代谢物的合成生物学方法

基本信息

批准号：
1804450
负责人：
金额：
--
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1804450
关键词：
Synthetic biology approaches production plant

项目摘要

Theme: Industrial Biotechnology and BioenergyPlants produce a wide variety of secondary metabolites that may have industrial applications as fuels, commodity chemicals, and therapeutic drugs. However, they are often produced in quantities that are too low for extraction to be economically viable. An alternative approach involves transferring the metabolic pathways required for biosynthesis of these natural products from the plant to a host that is better suited for industrial production. Microalgae possess unique properties that make them attractive prospects for such a host, including their capacity for phototrophic growth on waste streams such as carbon dioxide and wastewater. However, microalgae are relatively underdeveloped as industrial hosts, compared to more established platforms such as yeast. Synthetic biology is a novel development of genetic engineering that aims to facilitate the rational design and modification of biological systems by using a systematic engineering approach. This PhD project will the leverage tools and techniques developed in synthetic biology towards the metabolic engineering of plant secondary metabolites in microalgal hosts. This will involve discovering pathways in plants, transferring these pathways to algae, and using the knowledge gained in the process to construct synthetic metabolic pathways that generate novel products.ENWW:- Genomic analysis for identification of novel plant metabolic pathways- Systems biology analysis of transcriptomic and metabolomic data- Computational tools for the automated assembly and screening of synthetic metabolic pathways

主题：工业生物技术和BioEnergy Plants生产各种各样的次生代谢物，可能作为燃料、商品化学品和治疗药物具有工业应用。然而，它们的产量往往太低，不适合开采，在经济上是可行的。另一种方法是将这些天然产物的生物合成所需的代谢途径从植物转移到更适合工业生产的宿主。微藻具有独特的性质，使它们对这样的宿主具有吸引力，包括它们在二氧化碳和废水等废物流上进行光营养生长的能力。然而，与酵母等更成熟的平台相比，微藻作为工业宿主相对不发达。合成生物学是基因工程的一种新发展，其目的是利用系统工程方法促进生物系统的合理设计和修饰。这一博士项目将利用合成生物学中开发的工具和技术，在微藻宿主中对植物次生代谢物进行代谢工程。这将涉及发现植物中的途径，将这些途径转移到藻类，并利用在这个过程中获得的知识来构建产生新产品的合成代谢途径。ENWW：-用于识别新的植物代谢途径的基因组分析-转录和代谢组数据的系统生物学分析-用于自动组装和筛选合成代谢途径的计算工具