课题基金 / 基金详情

PROBING ELASTICITY WITH THE ATOMIC FORCE MICROSCOPE

PROBING ELASTICITY WITH THE ATOMIC FORCE MICROSCOPE
用原子力显微镜探测弹性
批准号：
6413460
负责人：
EMILIOS K DIMITRIADIS
金额：
$0.0万
依托单位：
OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6413460
关键词：
atomic force microscopy bioimaging /biomedical imaging elasticity gel method development nanotechnology

项目摘要

项目成果

EMILIOS K DIMITRIADIS的其他基金

相关文献

中文摘要
翻译
原子力显微镜（AFM）正日益成为在微观尺度上测量材料性质的第一线工具。然而，当涉及到细胞等软生物材料时，广泛使用的测量方法和数据分析方法都存在严重问题。在这里，我们开发了一种改进的实验方法，并开发了理论框架，用于分析收集的AFM 力-位移数据我们还建立了适用域的实验和理论框架。通过使用AFM提取软凝胶的弹性模量，然后将这些结果与宏观测量结果进行比较，验证了该项目的结果。
英文摘要
The atomic force microscope (AFM) is increasingly becoming a first line tool for measuring material properties at microscopic scales. When it comes to soft biological materials such as cells, however, serious problems have been identified with both the widely used measuring approach and with the data analysis methods. Here we develop an improved experimental approach and develop the theoretical framework for the analysis of collected AFM force-displacement data. We also establish the applicability domain for both the experimental and theoretical frameworks. The results of the project are being verified by extracting elastic moduli for soft gels using the AFM and then comparing those results with those obtained from macroscopic measurements.
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会议论文
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