POTENTIAL REDUCTION IN IMMUNE RESPONSE TO OPV BY SIMULTA

对接受口服脊髓灰质炎疫苗同时或不同时口服碘补充的儿童免疫前和免疫后的血清进行编码并检测对三种脊髓灰质炎病毒中的每一种的中和抗体滴度。该研究令人信服地证明，同时口服碘不会干扰婴儿对口服脊髓灰质炎疫苗的免疫反应，并且可以利用儿童免疫访问的机会通过口服碘化油来预防饮食性甲状腺功能减退。随着血清学研究的结论和结果在同行评议的文献中发表，该项目已经完成。根据GLP的管理报告和监督要求，建议将该清单保留到2001财年，作为研究档案记录的组成部分。

Pre- and post-immunization sera from children receiving OPV with or without simultaneous oral iodine supplementation were coded and tested for neutralizing antibody titers to each of the three types of poliovirus. The study convincingly demonstrated that simultaneous administration of oral iodine did not interfere with the immune response of infants to OPV and that the opportunity of childhood immunization visits can be used to prevent dietary hypothyroidism by oral administration of iodized oil. With the conclusion of the serological study and publication of the results in the peer-reviewed literature, this project has been completed. It is recommended that this listing be retained through FY 01 as a component of the study's archival record under management reporting and oversight requirements under GLP.