POTENTIAL REDUCTION IN IMMUNE RESPONSE TO OPV BY SIMULTA

对接受口服脊髓灰质炎疫苗（OPV）同时补充或不同时补充口服碘的儿童的免疫前和免疫后血清进行编码，并检测三种脊髓灰质炎病毒中每一种的中和抗体滴度。 该研究令人信服地证明，同时口服碘不会干扰婴儿对口服脊髓灰质炎疫苗的免疫反应，并且可以利用儿童免疫接种的机会通过口服碘油预防饮食性甲状腺功能减退症。 随着血清学研究的结束和结果在同行评审文献中的发表，该项目已经完成。建议将该列表保留至2001财年，作为GLP管理报告和监督要求下研究存档记录的组成部分。

Pre- and post-immunization sera from children receiving OPV with or without simultaneous oral iodine supplementation were coded and tested for neutralizing antibody titers to each of the three types of poliovirus. The study convincingly demonstrated that simultaneous administration of oral iodine did not interfere with the immune response of infants to OPV and that the opportunity of childhood immunization visits can be used to prevent dietary hypothyroidism by oral administration of iodized oil. With the conclusion of the serological study and publication of the results in the peer-reviewed literature, this project has been completed. It is recommended that this listing be retained through FY 01 as a component of the study's archival record under management reporting and oversight requirements under GLP.