POTENTIAL REDUCTION IN IMMUNE RESPONSE TO OPV BY SIMULTA

SIMULTA 可能降低 OPV 的免疫反应

• 批准号: 6436603
• 负责人: ROLF E TAFFS
• 金额: --
• 依托单位: BUREAU OF HEALTH PLANNING AND RESOURCES DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6436603
• 关键词: active immunization; antibody neutralization test; antibody titering; child (0-11); clinical research; dietary supplements; disease /disorder prevention /control; human subject; hypothyroidism; infant human (0-1 year); iodine; neutralizing antibody; nutrient drug interaction; nutrition related tag; oral administration; pediatric pharmacology; poliomyelitis vaccine; poliovirus

Pre- and post-immunization sera from children receiving OPV with or without simultaneous oral iodine supplementation were coded and tested for neutralizing antibody titers to each of the three types of poliovirus. The study convincingly demonstrated that simultaneous administration of oral iodine did not interfere with the immune response of infants to OPV and that the opportunity of childhood immunization visits can be used to prevent dietary hypothyroidism by oral administration of iodized oil. With the conclusion of the serological study and publication of the results in the peer-reviewed literature, this project has been completed. It is recommended that this listing be retained through FY 01 as a component of the study's archival record under management reporting and oversight requirements under GLP.

对接受口服脊髓灰质炎疫苗同时或不同时口服碘补充剂的儿童在免疫前和免疫后的血清进行编码，并对三种脊髓灰质炎病毒的中和抗体效价进行测试。这项研究令人信服地证明，同时口服碘不会干扰婴儿对OPV的免疫反应，儿童免疫访问的机会可以通过口服碘化油来预防饮食中的甲状腺功能减退。随着血清学研究的结束并将结果发表在同行评议的文献中，该项目已经完成。建议将这一清单保留到2001财年，作为普洛斯管理报告和监督要求下的研究档案记录的一部分。