POTENTIAL REDUCTION IN IMMUNE RESPONSE TO OPV BY SIMULTANEOUS ORAL IODINE SUPPLEM

同时口服碘补充可能降低 OPV 的免疫反应

• 批准号: 6293822
• 负责人: ROLF E TAFFS
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6293822
• 关键词: antibody neutralization test; chemoprevention; child (0-11); clinical research; dietary supplements; human subject; hypothyroidism; iodine; nutrient drug interaction; nutrition related tag; poliomyelitis vaccine

Pre- and post-immunization sera from children receiving OPV with or without simultaneous oral iodine supplementation were coded and tested for neutralizing antibody titers to each of the three types of poliovirus. The study convincingly demonstrated that simultaneous administration of oral iodine did not interfere with the immune response of infants to OPV and that the opportunity of childhood immunization visits can be used to prevent dietary hypothyroidism by oral administration of iodized oil.

对接受口服脊髓灰质炎疫苗（OPV）同时补充或不同时补充口服碘的儿童的免疫前和免疫后血清进行编码，并检测三种脊髓灰质炎病毒中每一种的中和抗体滴度。 该研究令人信服地证明，同时口服碘不会干扰婴儿对口服脊髓灰质炎疫苗的免疫反应，并且可以利用儿童免疫接种的机会通过口服碘油预防饮食性甲状腺功能减退症。