TYPE OF INFECTION ON EFFECTS OF ENDOTOXIN ANALOG

感染类型对内毒素类似物的影响

• 批准号: 6414070
• 负责人: Peter Q Eichacker
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6414070
• 关键词: analog; antitoxins; bacterial disease; blood toxicology; endotoxins

Clinical experience with anti-inflammatory agents in patients with sepsis has been disappointing to date. We have found that several factors such as the site, type, and severity of infection have important influences on many of these agents. Developing new agents which are impacted minimally by such factors, will increase the usefulness of this therapeutic approach. The role of endotoxin in the injury of sepsis is unclear. It is likely that under many circumstances it produces harmful effects. Targeting endotoxin rather than host mediators may be a more generally useful goal in sepsis. Antibodies against endotoxin have had little effect to date in sepsis because the toxic lipid portion of the molecule may be difficult to target. An alternative approach to neutralizing endotoxin uses analogue molecules which competitively inhibit cell signaling by endotoxin. We are currently performing a series of studies investigating the influence of site, severity, and type of infection on a competitive inhibitor of endotoxin.

迄今为止，脓毒症患者使用抗炎药的临床经验令人失望。我们已经发现，几个因素，如感染的部位，类型和严重程度有重要的影响，许多这些代理。开发受这些因素影响最小的新药物将增加这种治疗方法的有效性。内毒素在脓毒症损伤中的作用尚不清楚。在许多情况下，它可能产生有害影响。靶向内毒素而不是宿主介质可能是脓毒症中更普遍有用的目标。迄今为止，抗内毒素抗体在脓毒症中几乎没有效果，因为该分子的毒性脂质部分可能难以靶向。中和内毒素的替代方法使用竞争性抑制内毒素的细胞信号传导的类似物分子。我们目前正在进行一系列研究，调查感染部位、严重程度和类型对内毒素竞争性抑制剂的影响。