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INFLUENCE OF PREVIOUS INFECTION ON THE HOST DEFENSE EFFECTS OF GRANULOCYTE COLONY

INFLUENCE OF PREVIOUS INFECTION ON THE HOST DEFENSE EFFECTS OF GRANULOCYTE COLONY
既往感染对粒细胞集落宿主​​防御效应的影响
批准号:
6289412
负责人:
Peter Q Eichacker
金额:
$0.0万
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依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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英文摘要
Studies suggest that the production of endogenous anti-inflammatory agents during sepsis reduces host defense and predisposes to subsequent infection. Whether such a state of immunosuppression during sepsis actually exists or is reversible with the administration of proinflammatory agents is unclear. However, use of recombinant granu- locyte colony stimulating factor (G-CSF) to augment host defense following the onset of sepsis in critically ill patients has been proposed. Using a rat model, we plan to determine whether an initial episode of infection and sepsis augments the host defense effects of G- CSF during a subsequent episode.
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Effects of Therapeutic Recombinant Granulocyte Colony Stimulating Factor
  • 批准号:
    6227873
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    Peter Q Eichacker
  • 依托单位:
TYROSINE KINASE INHIBITION IN A CANINE MODEL OF S. AUREUS INFECTION
  • 批准号:
    6289408
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    Peter Q Eichacker
  • 依托单位:
TYPE OF INFECTION ON EFFECTS OF ENDOTOXIN ANALOG
  • 批准号:
    6414070
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    Peter Q Eichacker
  • 依托单位:
Influence Of Systemic Inflammation On The Effects Of Rec
  • 批准号:
    6546515
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    Peter Q Eichacker
  • 依托单位:
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